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>   home   >   Products   >   Primary Antibodies   >   Neuroscience   >   LRRC26 Antibody   

LRRC26 Antibody

     
  • WB - LRRC26 Antibody ASC11720
    Western blot analysis of LRRC26 in human prostate tissue lysate with LRRC26 antibody at 0.5 µg/ml in (A) the absence and (B) the presence of blocking peptide.
  • IHC - LRRC26 Antibody ASC11720
    Immunohistochemistry of LRRC26 in human prostate tissue with LRRC26 antibody at 2.5 µg/mL.
  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC, E
Primary Accession Q2I0M4
Other Accession NP_001013675, 61966761
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW Predicted: 37 kDa; Observed: 48 kDa
Application Notes LRRC26 antibody can be used for detection of LRRC26 by Western blot at 0.5 - 1 µg/ml. Antibody can also be used for immunohistochemistry starting at 2.5 µg/mL.
Additional Information
Gene ID 389816
Target/Specificity LRRC26; LRRC26 antibody is human specific.
Reconstitution & Storage LRRC26 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.
PrecautionsLRRC26 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name LRRC26
Synonyms CAPC
Function Auxiliary protein of the large-conductance, voltage and calcium-activated potassium channel (BK alpha). Required for the conversion of BK alpha channels from a high-voltage to a low- voltage activated channel type in non-excitable cells. These are characterized by negative membrane voltages and constant low levels of calcium.
Cellular Location Cell membrane; Single-pass type I membrane protein. Cytoplasm, cytoskeleton. Note=Localizes to the cytoplasm when expressed at high levels.
Tissue Location Isoform 1 is expressed highly in normal prostate and salivary gland, very weakly in colon, pancreas, and intestine, and not at all in other tissues. Isoform 1 is expressed highly in many cancer cell lines and in breast cancer, pancreatic cancer and colon cancer. Isoform 2 is expressed in cancer cell lines.
Research Areas
Citations (0)

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Background

The LRRC26 protein was initially identified as a cytokeratin-associated protein whose expression was elevated in multiple cancer cell lines and cancer specimens as well in normal prostate and salivary gland tissues (1). LRRC26 was later found to negatively regulate the NF-kappaB activation and suppresses tumor growth and metastasis (2). LRRC26 can also act to selectively alter the efficacy of large conductance calcium-activated K (BK) channels (3).

References

Egland KA, Liu XF, Squires S, et al. High expression of a cytokeratin-associated protein in many cancers. Proc. Natl. Acad. Sci. USA 2006; 103:5929-34.
Liu XF, Xiang L, Zhang Y, et al. CAPC negatively regulates NF-?B activation and suppresses tumor growth and metastasis. Oncogene 2012; 31:1673-82.
Almassy J and Begenisich T. The LRRC26 protein selectively alters the efficacy of BK channel activators. Mol. Pharmacol. 2012; 81:21-30.

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$ 320.00
Cat# ASC11720
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