|Application ||WB, IF, ICC, E|
|Other Accession||NP_065386, 10092625|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||Predicted: 20 kDa |
Observed: 25 kDa
|Application Notes||IL-22 antibody can be used for detection of IL-22 by Western blot at 1 - 2 µg/ml. Antibody can also be used for Immunocytochemistry starting at 5 µg/mL. For immunofluorescence start at 20 µg/mL.|
|Target/Specificity||IL22; IL-22 antibody is human, mouse, and rat reactive. Multiple isoforms of IL-22 are known to exist.|
|Reconstitution & Storage||IL-22 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.|
|Precautions||IL-22 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Cytokine that contributes to the inflammatory response in vivo.|
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Provided below are standard protocols that you may find useful for product applications.
Interleukin-22 (IL-22) is a cytokine important for the modulation of tissue responses during inflammation (1). Unlike the distantly related IL-10, IL-22 does not inhibit the production of proinflammatory cytokines in monocytes in response to LPS, but it has some inhibitory effects on IL-4 production from Th2 T cells. IL-22 is expressed by both the adaptive arm of the immune system such as CD4 T cell subsets including Th17 cells, as well as by innate lymphocytes such as NK and LTi-like cells (2). IL-22 is highly expressed in several chronic inflammatory conditions, and studies suggest that IL-22 plays both inflammatory and protective roles (3).
Xie MH, Aggarwal S, Ho WH, et al. Interleukin (IL)-22, a novel human cytokine that signals through the interferon receptor-related proteins CRF2-4 and IL-22R. J. Biol. Chem. 2000; 275:31335-9.
Wolk K, Kunz S, Witte E, et al. IL-22 increases the innate immunity of tissues. Immunity 2004; 21:241-54.
Wolk K, Witte E, Wallace E, et al. IL-22 regulates the expression of genes responsible for antimicrobial defense, cellular differentiation, and mobility in keratinocytes: a potential role in psoriasis. Eur. J. Immunol. 36:1309-23.
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