|Application ||WB, IHC-P, IF, E|
|Other Accession||NP_689992, 22749527|
|Calculated MW||Predicted: 26 kDa |
Observed: 23 kDa
|Application Notes||GLIPR1L1 antibody can be used for detection of GLIPR1L1 by Western blot at 1 - 2 µg/ml. Antibody can also be used for Immunohistochemistry starting at 5 µg/mL. For immunofluorescence start at 20 µg/mL.|
|Target/Specificity||GLIPR1L1; GLIPR1L1 antibody is human specific. At least two isoforms of GLIPR1L1 are known to exist; this antibody will detect both isoforms. This antibody is predicted to not cross-react with other GLIPR or GLIPR-like proteins.|
|Reconstitution & Storage||GLIPR1L1 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.|
|Precautions||GLIPR1L1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Tissue Location||Highly expressed in testis.|
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Provided below are standard protocols that you may find useful for product applications.
The GLIPR1-like 1 protein (GLIPR1L1) gene is part of a p53 target gene cluster that includes the related proteins GLIPR1 and GLIPR1L2 (1). GLIPR1L1 is similar to both the pathogenesis-related protein (PR) superfamily and the cysteine-rich secretory protein (CRISP) family (2). GLIPR1 is a tumor suppressor whose expression is regulated by p53 (3). Unlike GLIPR1, GLIPR1L1 is expressed primarily in the testis and is thought to be involved in the binding of sperm to the oocyte complex (4).
Ren C, Ren CH, Li L, et al. Identification and characterization of RTVP1/GLIPR1-like genes, a novel p53 target gene cluster. Genomics 2006; 88:163-72.
Murphy EV, Zhang Y, Zhu W, et al. The human glioma pathogenesis-related protein is structurally related to pathogenesis-related proteins and its gene is expressed specifically in brain tumors. Gene 1995; 159:131-5.
Ren C, Li L, Yang G, et al. RTVP-1, a tumor suppressor inactivated by methylation in prostate cancer. Cancer Res. 2004; 64:969-76.
Gibbs GM, Lo JC, Nixon B, et al. Glioma pathogenesis-related 1-like 1 is testis enriched, dynamically modified, and redistributed during male germ cell maturation and has a potential role in sperm-oocyte binding. Endocrinology 2010; 151:2332-42.
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