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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   GRK6 Antibody   

GRK6 Antibody

  • WB - GRK6 Antibody ASC11746
    Western blot analysis of GRK6 in rat small intestine tissue lysate with GRK6 antibody at 1 µg/ml.
  • IHC - GRK6 Antibody ASC11746
    Immunohistochemistry of GRK6 in human small intestine tissue with GRK6 antibody at 5 µg/mL.
  • IF - GRK6 Antibody ASC11746
    Immunofluorescence of GRK6 in human small intestine tissue with GRK6 antibody at 20 µg/mL.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P43250
Other Accession NP_001004106, 51896039
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW Predicted: 63 kDa

Observed: 63 kDa
Application Notes GRK6 antibody can be used for detection of GRK6 by Western blot at 1 - 2 µg/ml. Antibody can also be used for Immunohistochemistry starting at 5 µg/mL. For immunofluorescence start at 20 µg/mL.
Additional Information
Gene ID 2870
Target/Specificity GRK6; GRK6 antibody is human, mouse and rat reactive. Multiple isoforms of GRK6 are known to exist. This antibody is predicted to not cross-react with other members of the GRK protein family.
Reconstitution & Storage GRK6 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.
PrecautionsGRK6 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name GRK6
Synonyms GPRK6
Function Specifically phosphorylates the activated forms of G protein-coupled receptors. Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their desensitization. Seems to be involved in the desensitization of D2-like dopamine receptors in striatum and chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis (By similarity). Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor: LRP6 during Wnt signaling (in vitro).
Cellular Location Membrane; Lipid-anchor.
Tissue Location Widely expressed.
Research Areas
Citations (0)

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The G protein–coupled receptor kinases (GRKs) are a versatile family of kinases that play a critical role in cancer metastasis through their regulation of G-protein coupled receptors (GPCRs) involved in growth factor mediated cell migration (1,2). Phosphorylation of receptors by GRKs appears to be strictly dependent on the receptor being in its agonist-activated state (1). GRK6 is one of 7 members of the GRK serine/threonine kinase subfamily, which has been shown to modulate the Wnt signaling pathway via phosphorylation of LRP6 (3,4), and the insulin-like growth factor signaling pathway (4). GRK6 may also play a role in immune system function (5).


Inglese J, Freedman NJ, Koch WJ, et al. Structure and mechanism of the G protein-coupled receptor kinases. J. Biol. Chem. 1993; 268:23735-8.
Raghuwanshi SK, Smith N, Rivers EJ, et al. G protein-coupled receptor kinase 6 deficiency promotes angiogenesis, tumor progression, and metastasis. J. Immunol. 2013; 190:5329-36.
Benovic JL and Gomez J. Molecular cloning and expression of GRK6. A new member of the G protein-coupled receptor kinase family. J. Biol. Chem. 1993; 268:19521-7.
Chen M, Philipp M, Wang J, et al. G Protein-coupled receptor kinases phosphorylate LRP6 in the Wnt pathway. J. Biol. Chem. 2009; 284:35040-8.

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$ 310.00
Cat# ASC11746
(40 western blots)
Availability: 5-7days
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