|Other Accession||NP_941974, 38371724|
|Calculated MW||N/A KDa|
|Application Notes||Sin Nombre virus glycoprotein 2 antibody can detect 10ng Sin Nombre virus glycoprotein 2 peptide in ELISA at 1 µg/ml.|
|Reconstitution & Storage||Sin Nombre Glycoprotein 2 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.|
|Precautions||Sin Nombre Virus Glycoprotein 2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
Sin Nombre virus (SNV) is a rodent-borne hantavirus of the family Bunyaviridae, an enveloped, negative-sense RNA viruses with a tripartite genome that can cause hantavirus pulmonary syndrome (HPS) (1). Hantavirus glycoprotein precursor (GPC) is posttranslationally cleaved into two glycoproteins G1 (Gn) and G2 (Gc). While the G1 glycoprotein is is thought to be degraded by the host autophagy machinery, and this autophagic clearance is required for efficient virus repliaction (2), no such degradation was observed for the G2 glycoprotein.
Spiropoulou CF, Morzunov S, Feldmann H, et al. Genome structure and variability of a virus causing hantavirus pulmonary syndrome. Virology 1994; 200:715-23.
Hussein ITM, Cheng E, Ganaie SS, et al. Autophagic clearance of Sin Nombre hanatavirus glycoprotein Gn promotes virus replication in cells. J. Virol. 2012; 86:7520-9.
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