Foundational characteristics of cancer include proliferation, angiogenesis, migration, evasion of apoptosis, and cellular immortality. Find key markers for these cellular processes and antibodies to detect them.
The SUMOplot™ Analysis Program predicts and scores sumoylation sites in your protein. SUMOylation is a post-translational modification involved in various cellular processes, such as nuclear-cytosolic transport, transcriptional regulation, apoptosis, protein stability, response to stress, and progression through the cell cycle.
The Autophagy Receptor Motif Plotter predicts and scores autophagy receptor binding sites in your protein. Identifying proteins connected to this pathway is critical to understanding the role of autophagy in physiological as well as pathological processes such as development, differentiation, neurodegenerative diseases, stress, infection, and cancer.
Hantaan Virus Glycoprotein Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| E |
|---|---|
| Primary Accession | P08668 |
| Other Accession | BAA05012, 455464 |
| Reactivity | Virus |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | N/A KDa |
| Application Notes | Hantaan virus glycoprotein antibody can detect 10ng Hantaan virus glycoprotein peptide in ELISA at 1 µg/ml. |
| Gene ID | 2943079 |
|---|---|
| Target/Specificity | HTNVsMgp1; |
| Reconstitution & Storage | Hantaan virus glycoprotein antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. |
| Precautions | Hantaan Virus Glycoprotein Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | GP |
|---|---|
| Function | [Glycoprotein N]: Forms homotetramers with glycoprotein C at the surface of the virion. Attaches the virion to host cell receptors including integrin ITGAV/ITGB3 (PubMed:16310165, PubMed:31054291, PubMed:15657120). This attachment induces virion internalization predominantly through clathrin-dependent endocytosis (PubMed:11886265). May also bind to host C1QBP for virus entry into the host cell (PubMed:18834607). Mediates the assembly and budding of infectious virus particles through its interaction with the nucleocapsid protein and the viral genome (By similarity). May dysregulate normal immune and endothelial cell responses through an ITAM motif. Translocates to mitochondria, binds to host TUFM and recruits MAP1LC3B (PubMed:31091447). These interactions induce mitochondrial autophagy and therefore destruction of host MAVS leading to inhibition of type I interferon (IFN) responses (PubMed:31091447). Concomitant breakdown of glycoprotein N is apparently prevented by the nucleoprotein that may inhibit Gn-stimulated autophagosome-lysosome fusion (PubMed:31091447). Interacts with the viral genomic RNA (By similarity). |
| Cellular Location | [Glycoprotein N]: Virion membrane; Multi-pass membrane protein. Host cell surface. Host Golgi apparatus membrane; Multi-pass membrane protein. Host endoplasmic reticulum membrane; Multi-pass membrane protein. Host mitochondrion. Note=Interaction between glycoprotein N and glycoprotein C is essential for proper targeting of glycoprotein N to the host Golgi complex, where virion budding occurs {ECO:0000250|UniProtKB:P27312} |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
Hantaan virus (HNTV) is the prototype virus of the genus hantavirus of the family Bunyaviridae, an enveloped, negative-sense RNA virus that is the eiological agent of Korean hemorrhagic fever (1). The two glycoproteins of HNTV, G1 and G2, are encoded as a continuous open reading frame to produce a polypetide precursor which is then processed to yield two glycoproteins (2). During infection both glycoproteins are found in the Golgi complex and co-expression is considered as a prerequisite for localization to the Golgi complex (2).
References
Arikawa J, Lapenotiere HF, Iacono-Connors L, et al. Coding properties of the S and M genome segments of Sapporo rat virus: comparison to other causative agents of hemorrhagic fever with renal syndrome. Virology 1990; 176:114-25.
Pensiero MN and Hay J. The Hantaan virus M-segment glycoproteins G1 and G2 can be expressed independently. J. Virol. 1992; 66:1907-14.
If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abcepta.com.
Ordering Information
Other Products
Shipping Information
