|Other Accession||BAA05012, 455464|
|Calculated MW||N/A KDa|
|Application Notes||Hantaan virus glycoprotein antibody can detect 10ng Hantaan virus glycoprotein peptide in ELISA at 1 µg/ml.|
|Reconstitution & Storage||Hantaan virus glycoprotein antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.|
|Precautions||Hantaan Virus Glycoprotein Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Glycoprotein G1 and glycoprotein G2 interact with each other and are present at the surface of the virion. They are able to attach the virion to host cell receptors. This attachment induces virion internalization predominantly through clathrin- dependent endocytosis. Also promote fusion of viral membrane with host endosomal membrane after endocytosis of the virion. G1 contains an ITAM motif which is likely to dysregulate normal immune and endothelial cell responses and contribute to virus pathogenesis (By similarity).|
|Cellular Location||Glycoprotein G1: Virion membrane. Host Golgi apparatus membrane; Single-pass type I membrane protein. Host endoplasmic reticulum membrane; Single-pass type I membrane protein. Note=Interaction between G1 and G2 is essential for proper targeting of G1 to the Golgi complex, where virion budding occurs.|
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Provided below are standard protocols that you may find useful for product applications.
Hantaan virus (HNTV) is the prototype virus of the genus hantavirus of the family Bunyaviridae, an enveloped, negative-sense RNA virus that is the eiological agent of Korean hemorrhagic fever (1). The two glycoproteins of HNTV, G1 and G2, are encoded as a continuous open reading frame to produce a polypetide precursor which is then processed to yield two glycoproteins (2). During infection both glycoproteins are found in the Golgi complex and co-expression is considered as a prerequisite for localization to the Golgi complex (2).
Arikawa J, Lapenotiere HF, Iacono-Connors L, et al. Coding properties of the S and M genome segments of Sapporo rat virus: comparison to other causative agents of hemorrhagic fever with renal syndrome. Virology 1990; 176:114-25.
Pensiero MN and Hay J. The Hantaan virus M-segment glycoproteins G1 and G2 can be expressed independently. J. Virol. 1992; 66:1907-14.
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