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>   home   >   Products   >   Primary Antibodies   >   Puumala Virus Glycoprotein Antibody   

Puumala Virus Glycoprotein Antibody

     
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
E
Primary Accession P27312
Other Accession AFQ60650, 402502305
Reactivity Virus
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW N/A KDa
Application Notes Puumala virus glycoprotein antibody can detect 10ng Puumala virus glycoprotein peptide in ELISA at 1 µg/ml.
Additional Information
Gene ID 2943082
Target/Specificity PUUVsMgp1;
Reconstitution & Storage Puumala virus glycoprotein antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.
PrecautionsPuumala Virus Glycoprotein Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name GP
Function Glycoprotein N and Glycoprotein C interact with each other and are present at the surface of the virion. They are able to attach the virion to host cell receptors. This attachment induces virion internalization predominantly through clathrin- dependent endocytosis. Also promote fusion of viral membrane with host endosomal membrane after endocytosis of the virion. Glycoprotein N contains an ITAM motif which is likely to dysregulate normal immune and endothelial cell responses and contribute to virus pathogenesis (By similarity).
Cellular Location Glycoprotein N: Virion membrane {ECO:0000250|UniProtKB:P08668}. Host Golgi apparatus membrane {ECO:0000250|UniProtKB:P08668}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P08668}. Host endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P08668}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P08668}. Note=Interaction between Glycoprotein N and Glycoprotein C is essential for proper targeting of Glycoprotein N to the Golgi complex, where virion budding occurs.
Citations (0)

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Background

Puumala virus (PUUV) is a rodent-borne hantavirus of the family Bunyaviridae, an enveloped, negative-sense RNA viruses with a tripartite genome that can cause hantavirus pulmonary syndrome (HPS) and is highly homologous to the protype hantavirus Hantaan virus (1). Like other hantaviruses, the PUUV glycoprotein is synthesized as a precursor that is posttranslationally processed into two glycoproteins G1 (Gn) and G2 (Gc). These glycoproteins interact with the PUUV nucleocapsid (NP) protein through their cytoplasmic tail, and this association has been suggested to be crucial to the binding of the ribonucleoprotein of the PUUV and the assembly of the virus particle (2).

References

Vapalahti O, Kallio-Kokko H, Salonen EM, et al. Cloning and sequencing of Puumala virus Sotkamo strain S and M RNA segments: evidence for strain variation in hantaviruses and expression of the nucleocapsid protein. J. Gen. Virol. 1992; 73:829-38.
Hepojoki J, Strandin T, Wang H, et al. Cytoplasmic tails of hantavirus glycoproteins interact with the nucleocapsid protein. J. Gen. Virol. 2010; 91:2341-50.

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$ 320.00
Cat# ASC11759
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