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FMR1 Antibody

  • WB - FMR1 Antibody ASC11766
    Western blot analysis of FMR1 in rat brain tissue lysate with FMR1 antibody at 1 µg/ml.
  • IHC - FMR1 Antibody ASC11766
    Immunohistochemistry of FMR1 in human brain tissue with FMR1 antibody at 2.5 µg/mL.
  • IF - FMR1 Antibody ASC11766
    Immunofluorescence of FMR1 in human brain tissue with FMR1 antibody at 20 µg/mL.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q06787
Other Accession NP_002015, 4503765
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW Predicted: 70 kDa

Observed: 74 kDa
Application Notes FMR1 antibody can be used for detection of FMR1 by Western blot at 1 - 2 µg/ml. Antibody can also be used for Immunohistochemistry starting at 5 µg/mL. For immunofluorescence start at 20 µg/mL.
Additional Information
Gene ID 2332
Target/Specificity FMR1; FMR1 antibody is human, mouse and rat reactive. Multiple isoforms of FMR1 are known to exist.
Reconstitution & Storage FMR1 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.
PrecautionsFMR1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name FMR1
Function Translation repressor. Component of the CYFIP1-EIF4E- FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates translation repression (By similarity). RNA- binding protein that plays a role in intracellular RNA transport and in the regulation of translation of target mRNAs. Associated with polysomes. May play a role in the transport of mRNA from the nucleus to the cytoplasm. Binds strongly to poly(G), binds moderately to poly(U) but shows very little binding to poly(A) or poly(C).
Cellular Location Cytoplasm. Nucleus, nucleolus.
Tissue Location Highest levels found in neurons, brain, testis, placenta and lymphocytes. Also expressed in epithelial tissues and at very low levels in glial cells
Research Areas
Citations (0)

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Fragile X syndrome is a frequent form of inherited mental retardation caused by functional loss of the fragile X mental retardation protein, FMR1, also known as FMRP (1). FMR1 binds RNA and is associated with polysomes. The encoded protein may be involved in mRNA trafficking from the nucleus to the cytoplasm (2). A trinucleotide repeat (CGG) in the 5' UTR is normally found at 6-53 copies, but an expansion to 55-230 repeats is the cause of fragile X syndrome (1). Expansion of the trinucleotide repeat may also cause one form of premature ovarian failure (POF1) (3).


Jin P and Warren ST. Understanding the molecular basis of fragile X syndrome. Hum. Mol. Genet. 2000; 9:901-8.
Corbin F, Bouillon M, Fortin A, et al. The fragile X mental retardation protein is associated with poly(A)+ mRNA in actively translating polyribosomes. Hum. Mol. Genet. 1997; 1465-72.
Lu C, Lin L, Tan H, et al. Fragile X premutation RNA is sufficient to cause primary ovarian insufficiency in mice. Hum. Mol. Genet. 2012; 5039-47.

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$ 310.00
Cat# ASC11766
(40 western blots)
Availability: 5-7days
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