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TOPAZ1 Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, IF, E |
|---|---|
| Primary Accession | Q8N9V7 |
| Other Accession | NP_001138502, 222537754 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | Predicted: 65, 186 kDa Observed: 60, 240 kDa |
| Application Notes | TOPAZ1 antibody can be used for detection of TOPAZ1 by Western blot at 1 - 2 µg/ml. Antibody can also be used for Immunohistochemistry at 5 µg/mL. For Immunoflorescence start at 20 µg/mL. |
| Gene ID | 375337 |
|---|---|
| Target/Specificity | TOPAZ1; TOPAZ1 antibody is human, mouse and rat reactive. At least three isoforms of TOPAZ1 are known to exist. |
| Reconstitution & Storage | TOPAZ1 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. |
| Precautions | TOPAZ1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TOPAZ1 |
|---|---|
| Synonyms | C3orf77 |
| Function | Important for normal spermatogenesis and male fertility. Specifically required for progression to the post-meiotic stages of spermatocyte development. Seems to be necessary for normal expression levels of a number of testis-expressed gene transcripts, although its role in this process is unclear. |
| Cellular Location | Cytoplasm, cytosol {ECO:0000250|UniProtKB:E5FYH1} |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
The testis and ovary specific PAZ domain containing 1 (TOPAZ1) protein is a highly conserved protein that is highly expressed in the gonads during germ cell meiosis, suggesting that it may play a role in germ cell development (1). It contains a PAZ domain and a zinc finger domain and is exclusively expressed in adult testis and fetal ovary.
References
Baillet A, Le Bouffant R, Volff JN, et al. TOPAZ1, a novel germ cell-specific expressed gene conserved during evolution across vertebrates. PLoS One 2011; 6:e26950.
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