|Application ||WB, IHC-P, IF, E|
|Other Accession||NP_110419, 189571657|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||Predicted: 40, 67 kDa |
Observed: 52 kDa
|Application Notes||GDPD5 antibody can be used for detection of GDPD5 by Western blot at 1 - 2 µg/ml. Antibody can also be used for Immunohistochemistry at 5 µg/mL. For Immunoflorescence start at 20 µg/mL.|
|Target/Specificity||GDPD5; GDPD5 antibody is human, mouse and rat reactive. At least three isoforms of GDPD5 are known to exist.|
|Reconstitution & Storage||GDPD5 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.|
|Precautions||GDPD5 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Promotes neurite formation. Cooperates with PRDX1 to drive postmitotic motor neuron differentiation. The glycerophosphodiester phosphodiesterase activity may be required for its role in neuronal differentiation. May contribute to the osmotic regulation of cellular glycerophosphocholine.|
|Cellular Location||Endomembrane system; Multi- pass membrane protein. Cytoplasm, perinuclear region. Cell projection, growth cone. Note=In a punctate perinuclear pattern.|
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Provided below are standard protocols that you may find useful for product applications.
The glycerophosphodiester phosphodiesterase domain containing 5 (GDPD5) protein, also known as GDE2, is a seven transmembrane, widely expressed protein (1) that is necessary for spinal motor neuron differentiation and retinoid-induced neuronal outgrowth (2,3). Altered choline phospholipid metabolism is a hallmark of cancer, and the elevated expression of GDPD5 correlates with malignant choline phospholipid metabolite profiles in human breast cancer (4).
Nogusa Y, Fujioka Y, Komatsu R, et al. Isolation and characterization of two serpentine membrane proteins containing glycerophosphodiester phosphodiesterase, GDE2 and GDE6. Gene 2004; 337:173-9.
Rao M and Sockanathan S. Transmembrane protein GDE2 induces motor neuron differentiation in vivo. Science 2005; 309:2212-5.
Yanaka N, Nogusa Y, Fujioka Y, et al. Involvement of membrane protein GDE2 in retinoic acid-induced neurite formation in Neuro2A cells. FEBS Lett. 2007; 581:712-8.
Cao MD, Dopkens M, Krishnamachary B, et al. Glycerophosphodiester phosphodiesterase domain containing 5 (GDPD5) expression correlates with malignant choline phospholipid metabolite profiles in human breast cancer. NMR Biomed. 2012; 25:1033-42.
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