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OASL Antibody

  • WB - OASL Antibody ASC11792
    Western blot analysis of OASL in mouse bladder tissue lysate with OASL antibody at 1 µg/ml.
  • ICC - OASL Antibody ASC11792
    Immunocytochemistry of OASL1 in HepG2 cells with OASL1 antibody at 2.5 µg/mL.
  • IF - OASL Antibody ASC11792
    Immunofluorescence of OASL1 in HepG2 cells with OASL1 antibody at 20 µg/mL.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q15646
Other Accession NP_003724, 11321577
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW Predicted: 57 kDa

Observed: 65 kDa
Application Notes OASL antibody can be used for detection of OASL by Western blot at 1 - 2 µg/ml. Antibody can also be used for Immunocytochemistry at 2.5 µg/mL. For Immunoflorescence start at 20 µg/mL.
Additional Information
Gene ID 8638
Target/Specificity OASL; OASL antibody is human, mouse and rat reactive.
Reconstitution & Storage OASL antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.
PrecautionsOASL Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms TRIP14
Function Does not have 2'-5'-OAS activity, but can bind double- stranded RNA. Displays antiviral activity against encephalomyocarditis virus (EMCV) and hepatitis C virus (HCV) via an alternative antiviral pathway independent of RNase L.
Cellular Location Isoform p56: Nucleus, nucleolus. Cytoplasm.
Tissue Location Expressed in most tissues, with the highest levels in primary blood Leukocytes and other hematopoietic system tissues, colon, stomach and to some extent in testis
Research Areas
Citations (0)

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OASL (2'-5'-oligoadenylate synthetase-like), also known as p59OASL or TRIP14 (thyroid receptor-interacting protein 14), is a 514 amino acid protein that exists as two alternatively spliced isoforms, designated p56 and p30, and contains two ubiquitin-like domains (1). It is widely expressed in a variety of tissues and interacts with the ligand binding domain of the thyroid receptor (TR) and is able to bind double-stranded RNA and DNA, possibly playing a role in RNA degradation and the overall inhibition of protein synthesis (2-3). Methyl CpG-binding protein 1 (MBD1), which functions as a transcriptional repressor, was identified as a strong p59 OASL interactor (4).


Rebouillat D, Marie I, and Hovanessian AG. Molecular cloning and characterization of two related and interferon-induced 56 kDa and 30 kDa proteins highly similar to 2'-5' oligoadenylate synthetase. Eur. J. Biochem. 1998; 257:319-30.
Hartmann R, Olsen HS, Widder S, et al. p59OASL, a 2'-5' oligoadenylate synthetase like protein: a novel human gene related to the 2'-5' oligoadenylate synthetase family. Nucleic Acids Res. 1998; 26:4121-8.
Hovnanian A, Rebouillat D, Levy ER, et al. The human 2',5'-oligoadenylate synthetaselike gene (OASL) encoding the interferon-induced 56 kDa protein maps to chromosome 12q24.2 in the proximity of the 2',5'-OAS locus. Genomics 1999; 56:362-3.
Andersen JB, Strandbygård DJ, Hartmann R, et al. Interaction between the 2'-5' oligoadenylate synthetase-like protein p59 OASL and the transcriptional repressor methyl CpG-binding protein 1. Eur. J. Biochem. 2004; 271:628-36.

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$ 330.00
Cat# ASC11792
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