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NDST2 Antibody

  • WB - NDST2 Antibody ASC11818
    Western blot analysis of NDST2 in A-20 cell lysate with NDST2 antibody at 1 µg/ml in (A) the absence and (B) the presence of blocking peptide.
  • IF - NDST2 Antibody ASC11818
    Immunofluorescence of NDST2 in Daudi cells with NDST2 antibody at 20 µg/ml.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P52849
Other Accession NP_003626, 4505353
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW Predicted: 97 kDa

Observed: 101 kDa
Application Notes NDST2 antibody can be used for detection of PDCL by Western blot at 1 - 2 µg/ml. For immunofluorescence start at 20 µg/mL.
Additional Information
Gene ID 8509
Target/Specificity NDST2; NDST2 antibody is human, mouse and rat reactive. At least two isoforms of NDST2 are known to exist; this antibody will only detect the larger isoform. NDST2 antibody is predicted not to cross-react with other members of the NDST protein family.
Reconstitution & Storage NDST2 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.
PrecautionsNDST2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name NDST2
Synonyms HSST2
Function Essential bifunctional enzyme that catalyzes both the N- deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Plays a role in determining the extent and pattern of sulfation of heparan sulfate.
Cellular Location Golgi apparatus membrane; Single-pass type II membrane protein
Research Areas
Citations (0)

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The N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2 (NDST2) protein, also known as N-heparan sulfate sulfotransferase 2, and the highly related protein NDST1 have key roles in the sulfation of heparan sulfate proteoglycans, molecules that are present of cell surfaces and the extracellular matrix (1,2). NDST1 and NDST2 are dispensable for mesodermal differentiation into osteoblasts but necessary for induction of adipocytes and neural cells (3).


Humphries DE, Lanciotti J, and Karlinsky JB. cDNA cloning, genomic organization and chromosomal localization of human heparan glucosaminyl N-deacetylase/N-sulphotransferase-2. Biochem. J. 1998; 332:303-7.
Esko JD and Selleck SB. Order out of chaos. Assembly of ligand binding sites in heparan sulfate. Annu. Rev. Biochem. 2002; 71:435-71.
Forsberg M, Holmborn K, Kundu S, et al. Undersulfation of heparan sulfate restricts differentiation potential of mouse embryonic stem cells. J. Biol. Chem. 2012; 287:10853-62.

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$ 310.00
Cat# ASC11818
(40 western blots)
Availability: 5-7days
Bulk Size
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