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PDCL Antibody

  • WB - PDCL Antibody ASC11819
    Western blot analysis of PDCL in K562 cell lysate with PDCL antibody at 1 µg/ml.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q13371
Other Accession NP_005379, 88758594
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW Predicted: 33 kDa

Observed: 35 kDa
Application Notes PDCL antibody can be used for detection of PDCL by Western blot at 1 - 2 µg/ml.
Additional Information
Gene ID 5082
Target/Specificity PDCL; PDCL antibody is human, mouse and rat reactive. At least two isoforms of PDCL are known to exist. PDCL antibody is predicted to not cross-react with other members of the PDCL protein family.
Reconstitution & Storage PDCL antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.
PrecautionsPDCL Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms PHLOP1, PhLP1
Function Acts as a positive regulator of hedgehog signaling and regulates ciliary function. Isoform 2: Acts as a negative regulator of heterotrimeric G proteins assembly by trapping the preloaded G beta subunits inside the CCT chaperonin.
Cellular Location Cell projection, cilium {ECO:0000250|UniProtKB:Q9DBX2}
Citations (0)

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Phosducin-like proteins (PhLPs) are a conserved family of proteins with thioredoxin-like domains that were initially identified as modulators of G protein signaling (1,2). PDCL is widely expressed in normal human tissues and may participate directly in the regulation of calcium-evoked exocytosis in adrenal medullary chromaffin cells (3). It is an ethanol-responsive modulator of heterotrimeric G proteins (4).


Miles MF, Barhite S, Sganga M, et al. Phosducin-like protein: an ethanol-responsive potential modulator of guanine nucleotide-binding protein function. Proc. Natl. Acad. Sci. USA 1993; 90:10831-5.
Ruiz-Gomez A, Humrich J, Murga C, et al. Phosphorylation of phosducin and phosducinlike protein by G protein-coupled receptor kinase 2. J. Biol. Chem. 2000; 275:29724-30.
Gensse M, Vitale N, Chasserot-Golaz S, et al. Regulation of exocytosis in chromaffin cells by phosducin-like protein, a protein interacting with G protein betagamma-subunits. FEBS Lett. 2000; 480:184-8.
Barhite S, Thibault C, Miles MF, et al. Phosducin-like protein (PhLP), a regulator of G beta gamma function, interacts with the proteasomal protein SUG1. Biochim. Biophys. Acta 1998; 1402: 95-101.

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$ 330.00
Cat# ASC11819
Availability: 5-7days
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