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HDAC6 Antibody

  • WB - HDAC6 Antibody ASC11826
    Western blot analysis of HDAC6 in human testis tissue lysate with HDAC6 antibody at (A) 0.5 and (B) 1 µg/ml.
  • IHC - HDAC6 Antibody ASC11826
    Immunohistochemistry of HDAC6 in human testis tissue with HDAC6 antibody at 5 µg/ml.
  • IF - HDAC6 Antibody ASC11826
    Immunofluorescence of HDAC6 in human testis tissue with HDAC6 antibody at 20 µg/ml.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9UBN7
Other Accession NP_006035, 13128864
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW Predicted: 134 kDa

Observed: 145 kDa
Application Notes HDAC6 body can be used for detection of HDAC6 by Western blot at 0.5 - 1 µg/ml. Antibody can also be used for Immunohistochemistry starting at 5 µg/mL. For immunofluorescence start at 20 µg/mL.
Additional Information
Gene ID 10013
Target/Specificity HDAC6; HDAC6 antibody is human and mouse reactive. Multiple isoforms of HDAC6 are known to exist. HDAC6 antibody is predicted to not cross-react with other members of the HDAC family.
Reconstitution & Storage HDAC6 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.
PrecautionsHDAC6 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name HDAC6
Synonyms KIAA0901
Function Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). Plays a central role in microtubule-dependent cell motility via deacetylation of tubulin. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer.
Cellular Location Nucleus. Cytoplasm. Perikaryon. Cell projection, dendrite. Cell projection, axon. Note=It is mainly cytoplasmic, where it is associated with microtubules
Research Areas
Citations (0)

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The histone deacetylase (HDAC) family contains multiple members which are divided into four classes. Class II of the HDAC family comprises six members, HDAC4, 5, 6, 7, 9 and 10, each of which appear to have tissue-specific roles (1). HDAC6 contains an internal duplication of two catalytic domains which appear to function independently of each other (2). HDAC6 has been shown to be part of the microtubule network and acts as a specific alpha-tubulin deacetylase, and has been suggested to be a potential therapeutic target in neurodegenerative disease (3).


de Ruijter AJ, van Gennip AH, Caron HN, et al. Histone deacetylases (HDACs): characterization of the classical HDAC family. Biochem. J. 2003; 370:737-49.
Grozinger CM, Hassig CA, and Schrieber SL. Three proteins define a class of human histone deacetylases related to yeast Hda1p. Proc. Natl. Acad. Sci. USA 1999; 96:4868-73.
Li G, Jiang H, Chang M, et al. HDAC6: a-tubulin decetylase: a potential therapeutic target in neurodegenerative disease. J. Neurol. Sci. 2011; 304:1-8.

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$ 310.00
Cat# ASC11826
(40 western blots)
Availability: 5-7days
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