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>   home   >   Products   >   Primary Antibodies   >   Stem Cells   >   SOX17 Antibody   

SOX17 Antibody

  • WB - SOX17 Antibody ASC11830
    Western blot analysis of SOX17 in HepG2 cell lysate with SOX17 antibody at (A) 0.5 and (B) 1 µg/ml.
  • IF - SOX17 Antibody ASC11830
    Immunofluorescence of SOX17 in mouse liver tissue with SOX17 antibody at 20 µg/ml.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9H6I2
Other Accession NP_071899, 11967991
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW Predicted: 46 kDa

Observed: 42 kDa
Application Notes SOX17 antibody can be used for detection of SOX17 by Western blot at 0.5 - 1 µg/ml. For immunofluorescence start at 20 µg/mL.
Additional Information
Gene ID 64321
Target/Specificity SOX17; SOX17 antibody is human, mouse and rat reactive. SOX17 is predicted to not cross-react with other SOX proteins.
Reconstitution & Storage SOX17 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.
PrecautionsSOX17 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SOX17
Function Acts as transcription regulator that binds target promoter DNA and bends the DNA. Binds to the sequences 5'- AACAAT-'3 or 5'-AACAAAG-3'. Modulates transcriptional regulation via WNT3A. Inhibits Wnt signaling. Promotes degradation of activated CTNNB1. Plays a key role in the regulation of embryonic development. Required for normal looping of the embryonic heart tube. Required for normal development of the definitive gut endoderm. Probable transcriptional activator in the premeiotic germ cells (By similarity).
Cellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00267}
Tissue Location Expressed in adult heart, lung, spleen, testis, ovary, placenta, fetal lung, and kidney. In normal gastrointestinal tract, it is preferentially expressed in esophagus, stomach and small intestine than in colon and rectum
Research Areas
Citations (0)

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SOX17 is a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate (1,2). SOX17 is part of the SoxF subgroup which plays an important role in the differentiation of different cell types, including visceral and definitive endoderm and hematopoietic cell types (3,4). SOX17 is also essential for acquisition and maintenance of arterial identity (5).


Kanai Y, Kanai-Azuma M, Noce T, et al. Identification of two Sox17 messenger RNA isoforms, with and without the high mobility group box region, and their differential expression in mouse spermatogenesis. J. Cell Biol. 1996; 133:667-81.
Jiang T, Hou CC, She ZY, et al. The SOX gene family: function and regulation in testis determination and male fertility maintenance. Mol. Biol. Rep. 2013; 40:2187-94.
Francois M, Koopman P, and Beltrame M. SoxF genes: key players in the development of the cardiovascular system. Int. J. Biochem. Cell Biol. 2010; 42:445-8.
Kim I, Saunders TL, and Morrison SJ. Sox17 dependence distinguishes the transcriptional regulation of fetal from adult hematopoietic stem cells. Cell 2007; 130:470-83.

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$ 310.00
Cat# ASC11830
(40 western blots)
Availability: 5-7days
Bulk Size
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