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E2F3 Antibody

  • WB - E2F3 Antibody ASC11836
    Western blot analysis of E2F3 in human lymph node tissue lysate with E2F3 antibody at 1 µg/ml.
  • IHC - E2F3 Antibody ASC11836
    Immunohistochemistry of E2F3 in human lymph node tissue with E2F3 antibody at 5 µg/ml.
  • IF - E2F3 Antibody ASC11836
    Immunofluorescence of E2F3 in human lymph node tissue with E2F3 antibody at 20 µg/ml.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O00716
Other Accession NP_001940, 4503433
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW Predicted: 51 kDa

Observed: 56 kDa
Application Notes E2F3 antibody can be used for detection of E2F3 by Western blot at 1 - 2 µg/ml. Antibody can also be used for Immunohistochemistry starting at 5 µg/mL. For immunofluorescence start at 20 µg/mL.
Additional Information
Gene ID 1871
Target/Specificity E2F3; E2F3 antibody is human and mouse reactive. At least three isoforms of E2F3 are known to exist; this antibody will detect only the largest isoform. This antibody is predicted to not cross-react with other members of the E2F transcription factor family.
Reconstitution & Storage E2F3 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.
PrecautionsE2F3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name E2F3
Synonyms KIAA0075
Function Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC- 3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F3 binds specifically to RB1 in a cell-cycle dependent manner. Inhibits adipogenesis, probably through the repression of CEBPA binding to its target gene promoters (By similarity).
Cellular Location Nucleus.
Citations (0)

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The E2F transcription factor 3 (E2F3) is a member of a small family of transcription factors that function through binding of DP interaction partner proteins. E2F3 recognizes a specific sequence motif in DNA and interacts directly with the retinoblastoma protein (pRB) to regulate the expression of genes involved in the cell cycle (1). Like the related E2F1 and E2F2, E2F3 is essential for cellular proliferation and progression through the cell cycle (2). Altered copy number and activity of this gene have been observed in a number of human cancers (3).


Lees JA, Saito M, Vidal M, et al. The retinoblastoma protein binds to a family of E2F transcription factors. Mol. Cell. Biol. 1993; 13:7813-25.
Wu L, Timmers C, Maiti B, et al. The E2F1-3 transcription factors are essential for cellular proliferation. Nature 2001; 414:457-62.
DeGregori J. The genetics of the E2F family of transcription factors: shared functions and unique roles. Biochim. Biophys. Acta. 2002; 1602:131-50.

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$ 310.00
Cat# ASC11836
(40 western blots)
Availability: 5-7days
Bulk Size
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