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BAMBI Antibody

  • WB - BAMBI Antibody ASC11837
    Western blot analysis of BAMBI in mouse lung tissue lysate with BAMBI antibody at 1 µg/ml in (A) the absence and (B) the presence of blocking peptide.
  • IHC - BAMBI Antibody ASC11837
    Immunohistochemistry of BAMBI in human lung tissue with BAMBI antibody at 5 µg/ml.
  • IF - BAMBI Antibody ASC11837
    Immunofluorescence of BAMBI in human lung tissue with BAMBI antibody at 20 µg/ml.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q13145
Other Accession NP_036474, 6912534
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW Predicted: 29 kDa

Observed: 26 kDa
Application Notes BAMBI antibody can be used for detection of BAMBI by Western blot at 1 - 2 µg/ml. Antibody can also be used for Immunohistochemistry starting at 5 µg/mL. For immunofluorescence start at 20 µg/mL.
Additional Information
Gene ID 25805
Target/Specificity BAMBI; BAMBI antibody is human, mouse and rat reactive.
Reconstitution & Storage BAMBI antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.
PrecautionsBAMBI Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms NMA
Function Negatively regulates TGF-beta signaling.
Cellular Location Membrane; Single-pass type I membrane protein
Tissue Location High expression in kidney medulla, placenta and spleen; low in kidney cortex, liver, prostate and gut. Not expressed in normal skin, expression is high in melanocytes and in 3 out of 11 melanoma metastases tested
Research Areas
Citations (0)

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BAMBI (BMP and activin membrane-bound inhibitor homolog, NMA) is a membrane spanning glycoprotein that acts as a negative regulator of TGF-beta signaling during development (1). BAMBI transcription regulation is under the influence of beta-catenin, BMP, smad3 and smad4 (2,3). BAMBI expression can increase in colorectal and hepatocellular carcinomas relative to non-cancerous tissues (4). BAMBI is expressed at high levels during odontogenesis. BAMBI is coexpressed with Bmp-4 during early Xenopus embryogenesis and can be detected in poorly metastatic human melanoma cell lines (5).


Onichtchouk D, Chen YG, Dosch R, et al. Silencing of TGF-beta signalling by the pseudoreceptor BAMBI. Nature 1999; 401:480-5.
Yan X, Lin Z, Chen F, et al. Human BAMBI cooperates with Smad7 to inhibit transforming growth factor-beta signaling. J Biol. Chem. 2009; 284:30097-104.
Grotewold L, Plum M, Dildrop R, et al. Bambi is coexpressed with Bmp-4 during mouse embryogenesis. Mech. Dev. 2001; 100:327-30.
Fritzmann J, Morkel M, Besser D, et al. A colorectal cancer expression profile that includes transforming growth factor beta inhibitor BAMBI predicts metastatic potential. Gastroenterology 2009; 137:165-75.

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$ 330.00
Cat# ASC11837
Availability: 5-7days
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