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>   home   >   Products   >   Primary Antibodies   >   Cardiovascular   >   UVRAG Antibody   

UVRAG Antibody

  • WB - UVRAG Antibody ASC11845
    Western blot analysis of UVRAG in mouse lung tissue lysate with UVRAG antibody at 1 µg/ml.
  • IHC - UVRAG Antibody ASC11845
    Immunohistochemistry of UVRAG in human lung tissue with UVRAG antibody at 5 µg/ml.
  • IF - UVRAG Antibody ASC11845
    Immunofluorescence of UVRAG in human lung tissue with UVRAG antibody at 20 µg/ml.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9P2Y5
Other Accession NP_003360, 21687212
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW Predicted: 77 kDa

Observed: 75 kDa
Application Notes UVRAG antibody can be used for detection of UVRAG by Western blot at 1 - 2 µg/ml. Antibody can also be used for Immunohistochemistry starting at 5 µg/mL. For immunofluorescence start at 20 µg/mL.
Additional Information
Gene ID 7405
Target/Specificity UVRAG; UVRAG antibody is human and mouse reactive.
Reconstitution & Storage UVRAG antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.
PrecautionsUVRAG Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Cellular Location Late endosome. Lysosome. Early endosome. Note=Colocalizes with RAB9-positive compartments involved in retrograde transport from late endosomes to trans-Golgi network. Colocalization with early endosomes is only partial
Tissue Location Highly expressed in brain, lung, kidney and liver.
Research Areas
Citations (0)

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The class III type phosphoinositide 3-kinase (PI3KC3) / Vps34 regulates vacuolar trafficking as well as autophagy (1). UVRAG (UV radiation resistance-associated gene) is associated with the Beclin-1/PI3KC3 complex and promotes PI3KC3 enzymatic activity and autophagy, while suppressing proliferation (2). UVRAG is highly expressed in brain, lung, kidney and liver and contains one C2 domain, which is involved in calcium-dependent phospholipid binding. Beclin-1 binding to UVRAG promotes both autophagosome maturation and endocytic trafficking (3). UVRAG is also a potential tumor suppressor protein with frameshift mutations observed in colon and gastric carcinomas (4,5).


Stack JH, DeWald DB, Takegawa K, et al. Vesicle-mediated protein transport: regulatory interactions between the Vps15 protein kinase and the Vps34 PtdIns 3-kinase essential for protein sorting to the vacuole in yeast. J. Cell Biol. 1995; 129:321-34.
Liang C, Feng P, Ku B, et al. Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG. Nat. Cell Biol. 2006; 8:688-99.
Liang C, Lee JS, Inn KS, et al. Beclin1-binding UVRAG targets the class C Vps complex to coordinate autophagosome maturation and endocytic trafficking. Nat. Cell Biol. 2008; 10:776-87.
Ionov Y, Nowak N, Perucho M, et al. Manipulation of nonsense mediated decay identifies gene mutations in colon cancer Cells with microsatellite instability. Oncogene 2004; 23:639-45.

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$ 310.00
Cat# ASC11845
(40 western blots)
Availability: 5-7days
Bulk Size
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