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VEZT Antibody

     
  • WB - VEZT Antibody ASC11849
    Western blot analysis of VEZT in 293 cell lysate with VEZT antibody at (A) 1 and (B) 2 µg/ml.
    detail
  • IHC - VEZT Antibody ASC11849
    Immunohistochemistry of VEZT in rat kidney tissue with VEZT antibody at 5 µg/ml.
    detail
  • IF - VEZT Antibody ASC11849
    Immunofluorescence of TRIP12 in rat colon tissue with TRIP12 antibody at 20 µg/ml.
    detail
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession Q9HBM0
Other Accession NP_060069, 155030244
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW Predicted: 63, 68, 78, 81, 83, 86 kDa

Observed: 60 kDa
Application Notes VEZT antibody can be used for detection of VEZT by Western blot at 1 - 2 µg/ml. Antibody can also be used for Immunohistochemistry starting at 5 µg/mL. For immunofluorescence start at 20 µg/mL.
Additional Information
Gene ID 55591
Target/Specificity VEZT; VEZT antibody is human, mouse and rat reactive. Multiple isoforms are known to exist.
Reconstitution & Storage VEZT antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.
PrecautionsVEZT Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name VEZT
Function Plays a pivotal role in the establishment of adherens junctions and their maintenance in adult life. Required for morphogenesis of the preimplantation embryo, and for the implantation process.
Cellular Location Cell membrane; Multi-pass membrane protein. Cell projection, stereocilium membrane {ECO:0000250|UniProtKB:Q3ZK22}. Cell junction, adherens junction. Nucleus {ECO:0000250|UniProtKB:Q3ZK22}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250|UniProtKB:Q3ZK22}
Research Areas
Citations (0)
citation

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Background

Vezatin (VEZT) is a transmembrane protein which localizes to adherens junctions and binds to myosin VIIA and the cadherin-catenins complex (1). Expression of this gene in gastric cancer tissues is decreased due to hypermethylation of the promoter. Expression of this gene may also be inhibited by binding of a specific microRNA to a target sequence in the 3' UTR of the transcripts (2). VEZT has also been shown to be required for morphogenesis of the preimplantation mouse embryo (3).

References

Kussel-Andermann P, El-Amraoui A, Safieddine S, et al. Vezatin, a novel transmembrane protein, bridges myosin VIIA to the cadherin-catenins complex. EMBO J. 2000; 19:6020-9.
Guo X, Jing C, Zhang L, et al. Down-regulation of VEZT gene expression in human gastric cancer involves promoter methylation and miR-43c. Biochem. Biophys. Res. Commun. 2011; 404:622-7.
Hyenne V, Louvet-Vallee S, El-Amraoui A, et al. Vezatin, a protein associated to adherins junctions, is required for mouse blastocyst morphogenesis. Dev. Biol. 2005; 287:180-91.

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$ 379.00
Cat# ASC11849
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