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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   VEZT Antibody   

VEZT Antibody

  • WB - VEZT Antibody ASC11849
    Western blot analysis of VEZT in 293 cell lysate with VEZT antibody at (A) 1 and (B) 2 µg/ml.
  • IHC - VEZT Antibody ASC11849
    Immunohistochemistry of VEZT in rat kidney tissue with VEZT antibody at 5 µg/ml.
  • IF - VEZT Antibody ASC11849
    Immunofluorescence of TRIP12 in rat colon tissue with TRIP12 antibody at 20 µg/ml.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9HBM0
Other Accession NP_060069, 155030244
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW Predicted: 63, 68, 78, 81, 83, 86 kDa

Observed: 60 kDa
Application Notes VEZT antibody can be used for detection of VEZT by Western blot at 1 - 2 µg/ml. Antibody can also be used for Immunohistochemistry starting at 5 µg/mL. For immunofluorescence start at 20 µg/mL.
Additional Information
Gene ID 55591
Target/Specificity VEZT; VEZT antibody is human, mouse and rat reactive. Multiple isoforms are known to exist.
Reconstitution & Storage VEZT antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.
PrecautionsVEZT Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Function Plays a pivotal role in the establishment of adherens junctions and their maintenance in adult life. In case of Listeria infection, promotes bacterial internalization by participating in myosin VIIa recruitment to the entry site.
Cellular Location Cell membrane; Multi-pass membrane protein. Cell junction, adherens junction. Nucleus. Cytoplasmic vesicle, secretory vesicle, acrosome
Research Areas
Citations (0)

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Vezatin (VEZT) is a transmembrane protein which localizes to adherens junctions and binds to myosin VIIA and the cadherin-catenins complex (1). Expression of this gene in gastric cancer tissues is decreased due to hypermethylation of the promoter. Expression of this gene may also be inhibited by binding of a specific microRNA to a target sequence in the 3' UTR of the transcripts (2). VEZT has also been shown to be required for morphogenesis of the preimplantation mouse embryo (3).


Kussel-Andermann P, El-Amraoui A, Safieddine S, et al. Vezatin, a novel transmembrane protein, bridges myosin VIIA to the cadherin-catenins complex. EMBO J. 2000; 19:6020-9.
Guo X, Jing C, Zhang L, et al. Down-regulation of VEZT gene expression in human gastric cancer involves promoter methylation and miR-43c. Biochem. Biophys. Res. Commun. 2011; 404:622-7.
Hyenne V, Louvet-Vallee S, El-Amraoui A, et al. Vezatin, a protein associated to adherins junctions, is required for mouse blastocyst morphogenesis. Dev. Biol. 2005; 287:180-91.

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$ 320.00
Cat# ASC11849
Availability: 5-7days
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