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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   KIRREL2 Antibody   

KIRREL2 Antibody

     
  • WB - KIRREL2 Antibody ASC11854
    Western blot analysis of KIRREL2 in 293 cell lysate with KIRREL2 antibody at 1 µg/ml in (A) the absence and (B) the presence of blocking peptide.
  • IHC - KIRREL2 Antibody ASC11854
    Immunohistochemistry of KIRREL2 in human pancreas tissue with KIRREL2 antibody at 5 µg/ml.
  • IF - KIRREL2 Antibody ASC11854
    Immunofluorescence of KIRREL2 in human pancreas tissue with KIRREL2 antibody at 20 µg/ml.
  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession Q6UWL6
Other Accession NP_954649, 145275174
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW Predicted: 64, 70, 78 kDa

Observed: 70 kDa
Application Notes KIRREL2 antibody can be used for detection of KIRREL2 by Western blot at 1 - 2 µg/ml. Antibody can also be used for immunohistochemistry starting at 5 µg/mL. For immunofluorescence start at 20 µg/mL.
Additional Information
Gene ID 84063
Target/Specificity KIRREL2; KIRREL2 antibody is human, mouse and rat reactive. At least five isoforms are are known to exist. This antibody is predicted to not cross-react with other members of the KIRREL protein family.
Reconstitution & Storage KIRREL2 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.
PrecautionsKIRREL2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name KIRREL2
Synonyms NEPH3
Cellular Location Cell membrane; Single-pass type I membrane protein
Tissue Location Highly expressed in beta-cells of the pancreatic islets.
Research Areas
Citations (0)

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Background

KIRREL2, also known as nephrin-like 3, is a type I transmembrane protein belonging to the immunoglobulin superfamily of cell adhesion molecules (1). KIRREL2 consists of five extracellular Ig-like repeats, a transmembrane domain, several glycosylation sites and a cytoplasmic domain that has a stretch of nine conserved residues (1,2). KIRREL2 has been found to be expressed in beta cells of pancreatic islets and is involved in the regulation of both glomerular and neural development (3,4). Downregulation of KIRREL2 is implicated in several proteinuric diseases (4,5).

References

Sun C, Kilburn D, Lukashin A, et al. KIRREL2, a novel immunoglobulin superfamily gene expressed primarily in beta cells of the pancreatic islets. Genomics 2003; 82:130-42.
Heikkila E, Ristola M, Havana M, et al. Trans-interaction of nephrin and Neph1/Neph3 induces cell adhesion that associates with decreased tyrosine phosphorylation of nephrin. Biochem. J. 2011; 435:619-28.
Wang H, Lehtonen S, Chen YC, et al. Neph3 associates with regulation of glomerular and neural development in zebrafish. Differentiation 2012; 83:38-46.
Mizuhara E, Minaki Y, Nakatani T, et al. Purkinje cells originate from cerebellar ventricular zone progenitors positive for Neph3 and E-cadherin. Dev. Biol. 2010; 338:202-14.

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$ 320.00
Cat# ASC11854
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