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Beclin 2 Antibody

  • WB - Beclin 2 Antibody ASC11861
    Western blot analysis of Beclin 2 in Jurkat cell lysate with Beclin 2 antibody at 1 µg/ml in (A) the absence and (B) the presence of blocking peptide.
  • IHC - Beclin 2 Antibody ASC11861
    Immunohistochemistry of Beclin 2 in human lung carcinoma tissue with Beclin 2 antibody at 5 µg/ml.
  • IF - Beclin 2 Antibody ASC11861
    Immunofluorescence of Beclin 2 in human lung carcinoma tissue with Beclin 2 antibody at 20 µg/ml.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession A8MW95
Other Accession NP_001277622, 595582373
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW Predicted: 47 kDa

Observed: 55 kDa
Application Notes Beclin 2 antibody can be used for detection of Beclin 2 by Western blot at 1 - 2 µg/ml. Antibody can also be used for immunohistochemistry starting at 5 µg/mL. For immunofluorescence start at 20 µg/mL.
Additional Information
Gene ID 441925
Target/Specificity BECN1P1; Beclin 2 antibody is human specific. At least two isoforms of Beclin 2 are known to exist; this antibody will only detect the longer isoform. Beclin 2 antibody is predicted to not cross-react with Beclin 1.
Reconstitution & Storage Beclin 2 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.
PrecautionsBeclin 2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name BECN2 {ECO:0000303|PubMed:23954414, ECO:0000312|HGNC:HGNC:38606}
Function Involved in 2 distinct lysosomal degradation pathways: acts as a regulator of autophagy and as a regulator of G-protein coupled receptors turnover. Regulates degradation in lysosomes of a variety of G-protein coupled receptors via its interaction with GPRASP1/GASP1.
Cellular Location Cytoplasm.
Tissue Location Present in fetal and adult brain (at protein level).
Research Areas
Citations (0)

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Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells (1,2). Beclin 2 is a mammalian specific homolog of the autophagy protein Beclin 1 (3). Like Beclin 1, Beclin 2 interacts with Bcl-2 and class III PI3K complex components. However, Beclin 2 functions in an additional lysosomal degradation pathway and is required for ligand-induced endolysosomal degradation of several G protein-coupled receptors (3). Beclin 2 is also required for agonist-induced lysosome-mediated degradation of EGFR in lung cancer cells, suggesting that it may also play a role in regulating other intracellular signaling pathways (4).


Gozuacik D and Kimchi A. Autophagy as a cell death and tumor suppressor mechanism. Oncogene. 2004; 23:2891-906.
Kisen GO, Tessitore L, Costelli P, et al. Reduced autophagic activity in primary rat hepatocellular carcinoma and ascites hepatoma cells. Carcinogenesis 1993; 14:2501-5.
He C, Wei Y, Sun K, et al. Beclin 2 functions in autophagy, degradation of G protein-coupled receptors, and metabolism. Cell 2013; 154:1085-99.
Zhang W and He C. Regulation of plasma membrane receptors by a new autophagy-related BECN/Beclin family member. Autophagy 2014; 10: epub.

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$ 330.00
Cat# ASC11861
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