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GPRASP1 Antibody

  • WB - GPRASP1 Antibody ASC11863
    Western blot analysis of GPRASP1 in A-20 cell lysate with GPRASP1 antibody at 1 µg/ml in (A) the absence and (B) the presence of blocking peptide.
  • IHC - GPRASP1 Antibody ASC11863
    Immunohistochemistry of GPRASP1 in human breast carcinoma tissue with GPRASP12 antibody at 5 µg/ml.
  • IF - GPRASP1 Antibody ASC11863
    Immunofluorescence of GPRASP1 in human breast carcinoma tissue with GPRASP1 antibody at 20 µg/ml.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q5JY77
Other Accession NP_001171656, 9737
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW Predicted: 153 kDa; Observed: 150 kDa
Application Notes GPRASP1 antibody can be used for detection of GPRASP1 by Western blot at 1 - 2 μg/ml. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.
Additional Information
Gene ID 9737
Target/Specificity GPRASP1 antibody was raised against a 15 amino acid peptide near the amino terminus of human GPRASP1.

The immunogen is located within amino acids 260 - 310 of GPRASP1.
Reconstitution & Storage GPRASP1 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.
PrecautionsGPRASP1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms GASP, KIAA0443
Function Modulates lysosomal sorting and functional down- regulation of a variety of G-protein coupled receptors. Targets receptors for degradation in lysosomes via its interaction with BECN2.
Cellular Location Cytoplasm.
Tissue Location Expressed in the brain, with lower expression in medulla, spinal cord and substantia nigra
Research Areas
Citations (0)

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The G protein-coupled receptor associated sorting protein 1 (GPRASP1) is a member of the GPRASP family and is thought to modulate lysosomal sorting and functional down-regulation of a variety of G-protein coupled receptors (1,2). GPRASP1 interacts with receptors such as the D2 dopamine receptor (DRD2), delta opioid receptor (OPRD1), beta-2 adrenergic receptor (ADRB2), D4 dopamine receptor (DRD4) and cannabinoid 1 receptor (CNR1) and targets these proteins for degradation in lysosomes (2). Recently, it has been shown that increased GPRASP1 levels may act as a potential biomarker for breast cancer (3).


Simonin F, Karcher P, Boeuf JJ, et al. Identification of a novel family of G protein-coupled receptor associated proteins. J. Neurochem. 2004; 89:766-75.
Moser E, Kargl J, Whistler JL, et al. G protein-coupled receptor-associated sorting protein 1 regulates the postendocytic sorting of seven-transmembrane-spanning G protein-coupled receptors. Pharmacology 2010; 86:22-9.
Tuszynski GP, Rothman VL, Zheng X, et al. G-protein coupled receptor-associated sorting protein 1 (GASP-1), a potential biomarker in breast cancer. Exp. Mol. Pathol. 2011; 91:608-13.

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$ 330.00
Cat# ASC11863
Availability: 5-7days
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