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SESTRIN2 Antibody

  • WB - SESTRIN2 Antibody ASC11869
    Western blot analysis of SESTRIN2 in mouse kidney tissue lysate with SESTRIN2 antibody at 1 µg/ml in (A) the absence and (B) the presence of blocking peptide.
  • IHC - SESTRIN2 Antibody ASC11869
    Immunohistochemistry of SESTRIN2 in mouse kidney tissue with SESTRIN2 antibody at 5 µg/ml.
  • IF - SESTRIN2 Antibody ASC11869
    Immunofluorescence of SESTRIN2 in mouse kidney tissue with SESTRIN2 antibody at 20 µg/ml.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P58004
Other Accession NP_113647, 13899299
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW Predicted: 54 kDa

Observed: 53 kDa
Application Notes SESTRIN2 antibody can be used for detection of SESTRIN2 by Western blot at 1 - 2 µg/ml. Antibody can also be used for immunohistochemistry starting at 5 µg/mL. For immunofluorescence start at 20 µg/mL.
Additional Information
Gene ID 83667
Target/Specificity SESN2; SESTRIN2 antibody is human, mouse and rat reactive. At least two isoforms of SESTRIN2 are known to exist; this antibody will detect both isoforms. SESTRIN2 antibody is predicted to not cross-react with SESTRIN1.
Reconstitution & Storage SESTRIN2 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.
PrecautionsSESTRIN2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SESN2
Synonyms SEST2
Function Involved in the reduction of peroxiredoxins.
Tissue Location Widely expressed.
Research Areas
Citations (0)

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SESTRIN2, also known as Hi95, is a member of the sestrin family of PA26-related proteins and is induced following DNA damage or oxidative stress (1). SESTRIN2 and the related protein SESTRIN1 interact with the NRF2 suppressor KEAP1, the autophagy substrate p62 and the ubiquitin ligase RBX1 to protect cells against oxidative stress by activating NRF2 and promoting the p62-dependent autophagic degradation of KEAP1 (2). SESTRIN2 also negatively regulates TOR signaling by activating AMP-activated protein kinase (AMPK) and TSC2 phosphorylation (3), thereby protecting cells against energetic stress-induced death (4).


Budanov AV, Shoshani T, Faerman A, et al. Identification of a novel stress-responsive gene Hi95 involved in regulation of cell viability. Oncogene 2002; 21:6017-31.
Bae SH, Sung SH, Oh SY, et al. Sestrins activate Nrf2 by promoting p62-dependent autophagic degradation of Keap1 and prevent oxidative liver damage. Cell Metab. 2013; 17:73-84.
Budanov AV and Karin M. p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling. Mol. Cell 2008; 134:451-60.
Ben-Sahra I, Dirat B, Laurent K, et al. Sestrin2 integrates Akt and mTOR signaling to protect cells against energetic stress-induced death. Cell Death and Diff. 2013; 20:611-9.

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$ 310.00
Cat# ASC11869
(40 western blots)
Availability: 5-7days
Bulk Size
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