|Application ||WB, E|
|Other Accession||NP_003995, 42558283|
|Calculated MW||Predicted: 25 kDa |
Observed: 26 kDa
|Application Notes||GJB2 antibody can be used for detection of GJB2 by Western blot at 1 - 2 µg/ml.|
|Target/Specificity||GJB2; GJB2 antibody is human specific.|
|Reconstitution & Storage||GJB2 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.|
|Precautions||GJB2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|
|Cellular Location||Cell membrane; Multi-pass membrane protein. Cell junction, gap junction|
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Provided below are standard protocols that you may find useful for product applications.
The Gap junction beta-2 protein (GJB2), also known as Connexin 26, is member of the gap junction protein family which form structures that were shown to consist of cell-to-cell channels that facilitate the transfer of ions and small molecules between cells (1). Mutations in the GJB2 gene are thought to be responsible for as much as 35-45% of congenital sensorineural hearing loss in some populations (2). Other mutations in this gene have also been linked to a wide array of skin diseases (3).
Zhou JZ and Jiang JX. Gap junctions and hemichannel-independent actions of connexins on cell and tissue functions – An update. FEBS Lett. 2014; 588:1186-92.
Petit C, Levilliers J, and Hardelin JP. Molecular genetics of hearing loss. Annu. Rev. Genet. 2001; 35:589-646.
Gerido DA and White TW. Connexin disorders of the ear, skin, and lens. Biochim. Biophys. Acta. 2004; 1662:159-70.
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