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TAU Antibody

  • WB - TAU Antibody ASC11886
    Western blot analysis of TAU in SK-N-SH cell lysate with TAU antibody at 1 µg/ml.
  • IHC - TAU Antibody ASC11886
    Immunohistochemistry of TAU in mouse brain tissue with TAU antibody at 5 µg/ml.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P10636
Other Accession NP_058519, 294862261
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW Predicted: 83 kDa

Observed: 90 kDa
Application Notes TAU antibody can be used for detection of TAU by Western blot at 1 - 2 µg/ml. Antibody can also be used for immunohistochemistry starting at 5 µg/mL.
Additional Information
Gene ID 4137
Target/Specificity TAU; TAU antibody is human, mouse and rat reactive. Multiple isoforms of TAU are known to exist; this antibody will only detect the two longest isoforms.
Reconstitution & Storage TAU antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.
PrecautionsTAU Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms MAPTL, MTBT1, TAU
Function Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N- terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.
Cellular Location Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cell projection, axon. Note=Mostly found in the axons of neurons, in the cytosol and in association with plasma membrane components
Tissue Location Expressed in neurons. Isoform PNS-tau is expressed in the peripheral nervous system while the others are expressed in the central nervous system
Research Areas
Citations (0)

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The microtubial-associated protein TAU (MAPT), more commonly known as TAU, is is normally a highly soluble protein found predominantly in neurons (1), but accumulations of highly phosphorylated tau protein aggregates are observed in several neurodegenerative diseases including Alzheimer’s disease, progressive supranuclear palsy, corticobasal degeneration, and frontotemporal lobar dementia. It was thought that these pathological tau aggregates were the toxic form of tau, but recent studies indicate that soluble and highly phosphorylated tau species are more closely associated with synaptic dysfunction and cell loss (2,3). Mutations in the TAU gene have also been associated with several of these neurodegenerative diseases (4).


Dotti CG, Banker GA, and Binder LI. The expression and distribution of the microtubule-associated proteins tau and microtubule-associated protein 2 in hippocampal neurons in the rat in situ and in cell culture. Neuroscience 1987; 23:121-30.
Hanger DP, Brion JP, Gallo JM, et al. Tau in Alzheimer’s disease and Down’s syndrome is insoluble and abnormally phosphorylated. Biochem. J. 1991; 275:99–104.
Rocher AB, Crimins JL, Amatrudo JM, et al. Structural and functional changes in tau mutant mice neurons are not linked to the presence of NFTs. Exp. Neurol. 2010; 223:385–93.
Galimberti D and Scarpini E. Genetics and biology of Alzheimer’s disease and frontotemporal lobar degeneration. IInt. J. Clin. Exp. Med. 2010; 3:129-43.

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$ 310.00
Cat# ASC11886
(40 western blots)
Availability: 5-7days
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