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CTHRC1 Antibody

  • WB - CTHRC1 Antibody ASC11896
    Western blot analysis of CTHRC1 in rat small intestine tissue lysate with CTHRC1 antibody at (A) 1 and (B) 2 µg/ml.
  • IHC - CTHRC1 Antibody ASC11896
    Immunohistochemistry of CTHRC1 in human small intestine tissue with CTHRC1 antibody at 5 µg/mL.
  • IF - CTHRC1 Antibody ASC11896
    Immunofluorescence of CTHRC1 in human small intestine tissue with CTHRC1 antibody at 20 µg/mL.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q96CG8
Other Accession NP_612464, 19923989
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW Predicted: 27 kDa

Observed: 27 kDa
Application Notes CTHRC1 antibody can be used for detection of CTHRC1 by Western blot at 1 - 2 µg/mL. Antibody can also be used for immunohistochemistry starting at 5 µg/mL. For immunofluorescence start at 20 µg/mL.
Additional Information
Gene ID 115908
Target/Specificity CTHRC1; CTHRC1 antibody is human, mouse and rat reactive. At least two isoforms of CTHRC1 are known to exist; this antibody will detect only the larger isoform.
Reconstitution & Storage CTHRC1 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.
PrecautionsCTHRC1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Function May act as a negative regulator of collagen matrix deposition.
Cellular Location Secreted, extracellular space, extracellular matrix
Tissue Location Isoform 1 is expressed in calcified atherosclerotic plaque and chondrocyte-like cells
Research Areas
Citations (0)

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The Collagen triple helix repeat-containing protein (CTHRC1) is a glycosylated, secreted protein that is transiently expressed in the arterial wall in response to injury where it is thought to contribute to vascular remodeling by inhibiting collagen expression and deposition and promoting cell migration (1). CTHRC1 is highly expressed multiple human cancers, including pancreatic cancer where it plays a significant role in the progression and metastasis of the disease by regulating migration and adhesion of tumors cells (2). CTHRC1 overexpression can also be used as an independent prognostic marker in gastric cancer (3). Mutations at this locus have been associated with Barrett esophagus and esophageal adenocarcinoma (4).


Pyagay P, Heroult M, Wang Q, et al. Collagen triple helix repeat containing 1, a novel secreted protein in injured and diseased arteries, inhibits collagen expression and promotes cell migration. Circ. Res. 2005; 96:261-8.
Park EH, Kim S, Jo JY, et al. Collagen triple helix repeat containing-1 promotes pancreatic cancer progression by regulating migration and adhesion of tumor cells. Carcinogenesis 2013; 34:694-702.
Gu L, Liu L, Zhong L, et al. Cthrc1 overexpresion is an independent prognostic marker in gastric cancer. Hum. Pathol. 2014; 45:1031-8.
Orloff M, Peterson C, He X, et al. Germline mutations in MSR1, ASCC1, and CTHRC1 in patients with Barrett esophagus and esophageal adenocarcinoma. JAMA 2011; 306:410-9.

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$ 330.00
Cat# ASC11896
Availability: 5-7days
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