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IKZF2 Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, IF, E |
|---|---|
| Primary Accession | Q9UKS7 |
| Other Accession | NP_057344, 119220596 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | Predicted: 58 kDa Observed: 60 kDa |
| Application Notes | IKZF2 antibody can be used for detection of IKZF2 by Western blot at 1 - 2 µg/mL. Antibody can also be used for immunohistochemistry starting at 5 µg/mL. For immunofluorescence start at 20 µg/mL. |
| Gene ID | 22807 |
|---|---|
| Target/Specificity | IKZF2; IKZF2 antibody is human, mouse and rat reactive. At least two isoforms of IKZF2 are known to exist; this antibody will detect both isoforms. IKZF2 antibody is predicted to not cross-react with other IKZF proteins. |
| Reconstitution & Storage | IKZF2 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. |
| Precautions | IKZF2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | IKZF2 |
|---|---|
| Synonyms | HELIOS, ZNFN1A2 |
| Function | Associates with Ikaros at centromeric heterochromatin. |
| Cellular Location | Nucleus. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
The Ikaros family zinc finger 2 (IKZF2) is a member of the Ikaros family of zinc-finger proteins, a family of hematopoietic-specific transcription factors involved in the regulation of lymphocyte development (1,2). IKZF2 forms homo- or hetero-dimers with other Ikaros family members, and is thought to function predominantly in early hematopoietic development (3). Its expression is a marker for T cell activation and proliferation (4).
References
Hahm K, Cobb BS, McCarty AS, et al. Helios, a T cell-restricted Ikaros family member that quantitatively associates with Ikaros at centromeric heterochromatin. Genes Dev. 1998; 12:782-96.
John LB and Ward AC. The Ikaros gene family: transcriptional regulators of hematopoiesis and immunity. Mol. Immunol. 2011; 48:1272-8.
Kelly CM, Ikeda T, Koipally J, et al. Helios, a novel dimerization partner of Ikaros expressed in the earliest hematopoietic progenitors. Curr. Biol. 1998; 8:508-15.
Akimova T, Beier UH, Wang L, et al. Helios expression is a marker for T cell activation and proliferation. PLoS One 2011; 6:e24226.
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