|Application ||WB, IHC-P, IF, E|
|Other Accession||NP_057344, 119220596|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||Predicted: 58 kDa |
Observed: 60 kDa
|Application Notes||IKZF2 antibody can be used for detection of IKZF2 by Western blot at 1 - 2 µg/mL. Antibody can also be used for immunohistochemistry starting at 5 µg/mL. For immunofluorescence start at 20 µg/mL.|
|Target/Specificity||IKZF2; IKZF2 antibody is human, mouse and rat reactive. At least two isoforms of IKZF2 are known to exist; this antibody will detect both isoforms. IKZF2 antibody is predicted to not cross-react with other IKZF proteins.|
|Reconstitution & Storage||IKZF2 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.|
|Precautions||IKZF2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Associates with Ikaros at centromeric heterochromatin.|
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Provided below are standard protocols that you may find useful for product applications.
The Ikaros family zinc finger 2 (IKZF2) is a member of the Ikaros family of zinc-finger proteins, a family of hematopoietic-specific transcription factors involved in the regulation of lymphocyte development (1,2). IKZF2 forms homo- or hetero-dimers with other Ikaros family members, and is thought to function predominantly in early hematopoietic development (3). Its expression is a marker for T cell activation and proliferation (4).
Hahm K, Cobb BS, McCarty AS, et al. Helios, a T cell-restricted Ikaros family member that quantitatively associates with Ikaros at centromeric heterochromatin. Genes Dev. 1998; 12:782-96.
John LB and Ward AC. The Ikaros gene family: transcriptional regulators of hematopoiesis and immunity. Mol. Immunol. 2011; 48:1272-8.
Kelly CM, Ikeda T, Koipally J, et al. Helios, a novel dimerization partner of Ikaros expressed in the earliest hematopoietic progenitors. Curr. Biol. 1998; 8:508-15.
Akimova T, Beier UH, Wang L, et al. Helios expression is a marker for T cell activation and proliferation. PLoS One 2011; 6:e24226.
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