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DIRAS3 Antibody

  • WB - DIRAS3 Antibody ASC11908
    Western blot analysis of DIRAS3 in human testis tissue lysate with DIRAS3 antibody at 1 µg/ml.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O95661
Other Accession NP_004666, 4757772
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW Predicted: 25 kDa

Observed: 24 kDa
Application Notes DIRAS3 antibody can be used for detection of DIRAS3 by Western blot at 1 - 2 µg/ml.
Additional Information
Gene ID 9077
Target/Specificity DIRAS3; DIRAS3 antibody is human specific.
Reconstitution & Storage DIRAS3 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.
PrecautionsDIRAS3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms ARHI, NOEY2, RHOI
Cellular Location Cell membrane; Lipid-anchor; Cytoplasmic side
Tissue Location Expressed in normal ovarian and breast epithelial cells but not in ovarian and breast cancers
Research Areas
Citations (0)

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DIRAS3 is a member of the ras superfamily, and is expressed in normal ovarian and breast epithelial cells, but not in ovarian and breast cancers. It is an imprinted gene, with mono-allelic expression of the paternal allele, which is associated with growth suppression and down-regulation of cyclin D1 promoter activity and induction of p21 (WAF/CIP1). Thus, this gene appears to be a putative tumor suppressor gene whose function is abrogated in ovarian and breast cancers (1). DIRAS3 has been shown to induce autophagy in human ovarian cancer cells by blocking PI3K signaling, inhibiting the mammalian target of rapamycin (TOR), upregulating ATG4, and colocalizing with LC3 in autophagosomes (2). DIRAS also interacts with C-RAF and downregulates mitogen-activated protein kinase kinases (MEK) to restrict cell migration (3).


Yu Y, Xu F, Peng H, et al. NOEY2 (ARHI), an imprinted putative tumor suppressor gene in ovarian and breast carcinomas. Proc. Natl. Acad. Sci. USA 1999; 96:214-9.
Lu Z, Luo RZ, Lu Y, et al. The tumor suppressor gene ARHI regulates autophagy and tumor dormancy in human ovarian cancer cells. J. Clin. Invest. 2008; 118:3917-29.
Klingauf M, Beck M, Berge U, et al. The tumour suppressor DiRas3 interacts with C-RAF and downregulates MEK activity to restrict cell migration. Biol. Cell 2013; 105:91-107.

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$ 310.00
Cat# ASC11908
(40 western blots)
Availability: 5-7days
Bulk Size
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