|Application ||WB, E|
|Other Accession||NP_061072, 194328758|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||Predicted: 41, 44, 47 kDa |
Observed: 40 kDa
|Application Notes||DNAJA4 antibody can be used for detection of DNAJA4 by Western blot at 1 - 2 µg/ml.|
|Target/Specificity||DNAJA4; DNAJA4 antibody is human, mouse, and rat reactive. At least three isoforms of DNAJA4 are known to exist; this antibody will detect all three isoforms.|
|Reconstitution & Storage||DNAJA4 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.|
|Precautions||DNAJA4 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Cellular Location||Membrane; Lipid-anchor|
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Provided below are standard protocols that you may find useful for product applications.
The DNAJA4 protein is the mammalian homolog of the chaperone HSP40 (1) and acts as a co-chaperone with the heat shock protein HSP70 (2). DNAJA4 is highly expressed in heart and testis, accounting for approximately 1% of total protein in mouse heart (2). DNAJA4 is also regulated by the sterol regulatory element binding transcription factor 2 (SREBF2) and plays a role in the synthesis of cholesterol (3).
Ohtsuka K and Hata M. Mammalian HSP40/DNAJ homologs: cloning of novel cDNAs and a proposal for their classification and nomenclature. Cell Stress Chaperones 2000; 5:98-112.
Abdul KM, Terada K, Gotoh T, et al. Characterization and functional analysis of a heart-enriched DnaJ / Hsp40 homolog dj4/DjA4. Cell Stress Chaperones 2002; 7:156-66.
Robichon C, Varret M, Le Liepvre X, et al. DnajA4 is a SREBP-regulated chaperone involved in the cholesterol biosynthesis pathway. Biochim. Biophys. Acta 2006; 1761:1107-13.
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