|Application ||WB, IHC-P, IF, E|
|Other Accession||NP_001073946, 122937400|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||Predicted: 297 kDa |
Observed: 300 kDa
|Application Notes||TENM3 antibody can be used for detection of TENM3 by Western blot at 1 - 2 µg/mL. Antibody can also be used for immunohistochemistry starting at 5 µg/mL. For immunofluorescence start at 20 µg/mL.|
|Target/Specificity||TENM3; TENM3 antibody is human, mouse and rat reactive. TENM3 antibody is predicted to not cross-react with other members of the TENM family.|
|Reconstitution & Storage||TENM3 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.|
|Precautions||TENM3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||KIAA1455, ODZ3, TNM3|
|Function||Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Promotes axon guidance and homophilic cell adhesion. Plays a role in the development of the visual pathway; regulates the formation in ipsilateral retinal mapping to both the dorsal lateral geniculate nucleus (dLGN) and the superior colliculus (SC). May be involved in the differentiation of the fibroblast-like cells in the superficial layer of mandibular condylar cartilage into chondrocytes. May function as a cellular signal transducer (By similarity).|
|Cellular Location||Membrane; Single-pass membrane protein. Cell projection, axon|
|Tissue Location||Expressed in adult and fetal brain, slightly lower levels in testis and ovary, and intermediate levels in all other peripheral tissues examined. Not expressed in spleen or liver. Expression was high in brain, with highest levels in amygdala and caudate nucleus, followed by thalamus and subthalamic nucleus.|
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Provided below are standard protocols that you may find useful for product applications.
The teneurin transmembrane protein 3 (TENM3) is a member of a family of four neuronal cell surface proteins homologous to the Drosophila pair-rule gene Ten-m (1,2). TENM3 is expressed in cartilaginous cells during postnatal growth in mice (3), as well as the adult eye and optic stalk (4). Homozygous null mutations in TENM3 causes microphthalmia in humans (5).
Ben-Zur T and Wides R. Mapping homologs of Drosophila odd oz (odz): Doc4/Odz to mouse chromosome 7, Odz1 to mouse chromosome 11; and ODZ3 to human chromosome Xq25. Genomics 1999; 58:102-3.
Rubin BP, Tucker RP, Martin D, et al. Tenurins: a novel family of neuronal cell surface proteins in vertebrates, homologous to the Drosophila pair-rule gene Ten-m. Dev. Biol. 1999; 216:195-209.
Murakami T, Fukunaga T, Takeshita N, et al. Expression of Ten-m/Odz3 in the fibrous layer of madibular condylar cartilage during postnatal growth in mice. J. Anat. 2010; 217:236-44.
Ben-Zur T, Feige E, Motro B, et al. The mammalian Odz gene family: homologs of a Drosophila pair-rule gene with expression implying distinct yet overlapping developmental roles. Dev. Biol. 2000; 217:107-20.
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