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SNRPN Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, IF, E |
|---|---|
| Primary Accession | P63164 |
| Other Accession | NP_003088, 4507135 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | Predicted: 26 kDa Observed: 25 kDa |
| Application Notes | SNRPN antibody can be used for detection of SNRPN by Western blot at 0.5 - 1 µg/mL. Antibody can also be used for immunohistochemistry starting at 5 µg/mL. For immunofluorescence start at 20 µg/mL. |
| Gene ID | 6638 |
|---|---|
| Target/Specificity | SNRPN; SNRPN antibody is human, mouse and rat reactive. |
| Reconstitution & Storage | SNRPN antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. |
| Precautions | SNRPN Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | Snrpn |
|---|---|
| Synonyms | Smn |
| Function | May be involved in tissue-specific alternative RNA processing events. |
| Cellular Location | Nucleus. |
| Tissue Location | Brain specific. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The small nuclear riboprotein-associated protein N (SNRPN) is one polypeptide of a small nuclear ribonucleoprotein complex and belongs to the snRNP SMB/SMN family. SNRPN plays a role in pre-mRNA processing and alternative splicing (1). SNRPN arises from a bicistronic transcript that also encodes a protein identified as the SNRPN upstream reading frame (SNURF) (2). Mutations or deletions in the SNRPN gene may be linked to responsible for Angelman syndrome or Prader-Willi syndrome (3).
References
Ozcelik T, Leff S, Robinson W, et al. Small nuclear ribonucleoprotein polypeptide N (SNRPN), an expressed gene in the Prader-Willi syndrome critical region. Nat. Genet. 1992; 2:265-9.
Gray TA, Saitoh S, and Nicholls RD. An imprinted, mammalian bicistronic transcript encodes two independent proteins. Proc. Natl. Acad. Sci. USA 1999; 96:5616-21.
Chen Y, Liu YJ, Pei YF, et al. Copy number variations at the Prader-Willi syndrome region on chromosome 15 and associations with obesity in whites. Obesity 2011; 19:1229-34.
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