|Application ||WB, E|
|Other Accession||NP_061324, 9055278|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||Predicted: 45 kDa |
Observed: 48 kDa
|Application Notes||AJAP1 antibody can be used for detection of AJAP1 by Western blot at 1 - 2 µg/ml.|
|Target/Specificity||AJAP1; AJAP1 antibody is human, mouse and rat reactive.|
|Reconstitution & Storage||AJAP1 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.|
|Precautions||AJAP1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays a role in cell adhesion and cell migration.|
|Cellular Location||Basolateral cell membrane; Single-pass type III membrane protein. Apical cell membrane; Single-pass type III membrane protein. Cell junction, adherens junction. Note=Mainly basolateral. Localization is mediated by AP1M2|
|Tissue Location||Expressed in uterus and pancreas (at protein level).|
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Provided below are standard protocols that you may find useful for product applications.
The Adherens Junction Associated Protein 1 (AJAP1) plays a key role in cell adhesion and cell migration (1). It is a transmembrane protein found on the basolateral surface of epithelium and expressed by multiple types of epithelium (1,2). AJAP1 interacts with E-Cadherin and appears to promote the internalization of E-Cadherin upon growth factor stimulation (3). This facilitates the dissolution of adherens junctions with an increase in cell motility (3,4).
Zeng L, Fee BE, Rivas MV, et al. Adherens junctional associated protein-1: a novel 1p36 tumor suppressor candidate in gliomas (Review). Int. J. Oncol. 2014; 45:13-7.
Han L, Zhang KL, Zhang JX, et al. AJAP1 is dysregulated at an early stage of gliomagenesis and suppresses invasion through cytoskeleton reorganization. CNS Neurosci. Ther. 2014; 20:429-37.
Gross JC, Schreiner A, Engels K, et al. E-cadherin surface levels in epithelial growth factor-stimulated cells depend on adherens junction protein shrew-1. Mol. Biol. Cell 2009; 20:3598-607.
Lin N, Di C, Bortoff K, et al. Deletion or epigenetic silencing of AJAP1 on 1p36 in glioblastoma. Mol. Cancer Res. 2012; 10:208-17.
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