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QSOX1 Antibody

  • WB - QSOX1 Antibody ASC11921
    Western blot analysis of QSOX1 in EL4 cell lysate with QSOX1 antibody at (A) 1 and (B) 2 µg/ml.
  • IF - QSOX1 Antibody ASC11921
    Immunofluorescence of QSOX1 in human spleen tissue with QSOX1 antibody at 20 µg/mL.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O00391
Other Accession NP_002817, 13325075
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW Predicted: 65, 82 kDa; Observed: 66 kDa
Application Notes QSOX1 antibody can be used for detection of QSOX1 by Western blot at 1 - 2 µg/ml. For immunofluorescence start at 20 µg/mL.
Additional Information
Gene ID 5768
Target/Specificity QSOX1; QSOX1 antibody is human and mouse reactive. QSOX1 antibody is predicted to not cross-react with QSOX2.
Reconstitution & Storage QSOX1 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.
PrecautionsQSOX1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name QSOX1
Synonyms QSCN6
Function Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. May contribute to disulfide bond formation in a variety of secreted proteins. In fibroblasts, it may have tumor- suppressing capabilities being involved in growth regulation.
Cellular Location Isoform 1: Golgi apparatus membrane; Single- pass membrane protein
Tissue Location Expressed in heart, placenta, lung, liver, skeletal muscle, pancreas and very weakly in brain and kidney {ECO:0000269|PubMed:10708601, ECO:0000269|Ref.9}
Research Areas
Citations (0)

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The QSOX1 gene, also known as Quiescin Q6, is a fusion of two ancient genes: thioredoxin and ERV1. Its expression is induced as fibroblasts begin to exit the proliferative cycle and enter quiescence, suggesting that this gene plays an important role in growth regulation (1). The QSOX1 protein oxidizes sulfhydryl groups to form disulfide bonds in proteins. QSOX1 expression is induced by hypoxia (2) and appears to protect cells against oxidative stress-induced apoptosis (3).


Coppock DL, Cina-Poppe D, and Gilleran S. The quiescin Q6 gene (QSCN6) is a fusion of two ancient gene families: thioredoxin and ERV1. Genomics 1998; 54:460-8.
Shi CY, Fan Y, Liu B, et al. HIF1 contributes to hypoxia-induced pancreatic cancer cells invasion via promoting QSOX1 expression. Cell Physiol. Biochem. 2013; 32:561-8.
Morel C, Adami P, Musard JF, et al. Involvement of sulfhydryl oxidase QSOX1 in the protection of cells against oxidative stress-induced apoptosis. Exp. Cell Res. 2007; 313:3971-82.

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$ 310.00
Cat# ASC11921
(40 western blots)
Availability: 5-7days
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