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>   home   >   Products   >   Primary Antibodies   >   Microbiology   >   PACS2 Antibody   

PACS2 Antibody

     
  • IHC - PACS2 Antibody ASC11928
    Immunohistochemistry of NogoA in mouse brain tissue with NogoA Antibodyat 5 µg/mL.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession Q86VP3
Other Accession NP_056012, 23241
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW Predicted: 98 kDa

Observed: 95 kDa
Application Notes PACS2 antibody can be used for detection of PACS2 by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL.
Additional Information
Gene ID 23241
Target/Specificity PACS2 antibody was raised against a 17 amino acid peptide near the center of human PACS2.

The immunogen is located within amino acids 330 - 380 of PACS2.
Reconstitution & Storage PACS2 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.
PrecautionsPACS2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PACS2
Synonyms KIAA0602, PACS1L
Function Multifunctional sorting protein that controls the endoplasmic reticulum (ER)-mitochondria communication, including the apposition of mitochondria with the ER and ER homeostasis. In addition, in response to apoptic inducer, translocates BIB to mitochondria, which initiates a sequence of events including the formation of mitochondrial truncated BID, the release of cytochrome c, the activation of caspase-3 thereby causing cell death. May also be involved in ion channel trafficking, directing acidic cluster-containing ion channels to distinct subcellular compartments.
Cellular Location Endoplasmic reticulum lumen. Mitochondrion
Tissue Location Broadly expressed, with greatest levels in skeletal muscle followed by heart, brain, pancreas and testis
Research Areas
Citations (0)

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Background

PACS2 (phosphofurin acidic cluster sorting protein-2), PACS1L, is an 889 amino acid protein that localizes to both the mitochondrion and the lumen of the endoplasmic reticulum (ER) and belongs to the PACS family (1,2). It is expressed in a broad range of tissues with highest expression in skeletal muscle, brain, heart, testis and pancreas (2,). PACS2 interacts with Polycystin-2 and BID and functions as a sorting protein that regulates mitochondria-ER communication and is thought to be involved in ion channel trafficking, specifically direct cluster-containing ion channels to distinct subcellular compartments (3-5).

References

Kottgen M, Benzing T, Simmen T, et al. Trafficking of TRPP2 by PACS proteins represents a novel mechanism of ion channel regulation. EMBO J. 2005; 24:705-16.
Brasacchio D, Noori T, House C, et al. A functional genomics screen identifies PCAF and ADA3 as regulators of human granzyme B-mediated apoptosis and Bid cleavage. Cell Death Differ. 2014; 21:748-60.
Werneburg NW, Bronk SF, Guicciardi ME, et al. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) protein-induced lysosomal translocation of proapoptotic effectors is mediated by phosphofurin acidic cluster sorting protein-2 (PACS-2). J. Biol. Chem. 2012; 287:24427-37.
You H and Thomas G. A homeostatic switch in PACS-2 links membrane traffic to TRAIL-induced apoptosis. Cell Cycle 2009; 8:2679-80.

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$ 320.00
Cat# ASC11928
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