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KIR2DS2 Antibody

     
  • WB - KIR2DS2 Antibody ASC11933
    Western blot analysis of KIR2DS2 in 293 cell lysate with KIR2DS2 antibody at (A) 1 and (B) 2 µg/ml.
  • IF - KIR2DS2 Antibody ASC11933
    Immunofluorescence of KIR2DS2 in 293 cells with KIR2DS2 antibody at 20 µg/ml.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IF, E
Primary Accession P43631
Other Accession NP_036444, 6912472
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW Predicted: 28, 33, 37 kDa

Observed: 34, 42 kDa
Application Notes KIR2DS2 antibody can be used for detection of KIR2DS2 by Western blot at 1 - 2 µg/ml. For immunofluorescence start at 20 µg/mL.
Additional Information
Gene ID 100132285
Target/Specificity KIR2DS2; KIR2DS2 antibody is human specific. Multiple isoforms are known to exist.
Reconstitution & Storage KIR2DS2 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.
PrecautionsKIR2DS2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name KIR2DS2
Synonyms CD158J, NKAT5
Function Receptor on natural killer (NK) cells for HLA-C alleles. Does not inhibit the activity of NK cells.
Cellular Location Cell membrane; Single-pass type I membrane protein
Research Areas
Citations (0)

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Background

Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells (1). The KIR proteins are classified by the number of extracellular immunoglobulin domains and by whether they have a long (L) or short (S) cytoplasmic domain (2,3). KIR proteins are thought to play an important role in regulation of the immune response (3). KIR2DS2 downregulates the cytotoxicity of NK cells upon recognition of specific class I major histocompatibility complex (MHC) molecules on target cells and is a receptor on natural killer (NK) cells for HLA-C alleles (3,4).

References

Colonna M and Samaridis J. Cloning of immunoglobulin-superfamily members associated with HLA-C and HLA-B recognition by human natural killer cells. Science 1995; 268:405-8.
Biassoni R, Cantoni C, Falco M, et al. The human leukocyte antigen (HLA)-C-specific "activatory" or "inhibitory" natural killer cell receptors display highly homologous extracellular domains but differ in their transmembrane and intracytoplasmic portions. J. Exp. Med. 1996; 183:645-50.
Wagtmann N, Biassoni R, Cantoni C, et al. Molecular clones of the p58 NK cell receptor reveal immunoglobulin-related molecules with diversity in both the extra- and intracellular domains. Immunity 1995; 2:439-49.
Moesta AK and Parham P. Diverse functionality among human NK cell receptors for the C1 epitope of HLA-C: KIR2DS2, KIR2DL2, and KIR2DL3. Front. Immunol. 2012; 3:336.

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$ 310.00
Cat# ASC11933
Size:
Quantity:
(40 western blots)
Availability: 5-7days
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