|Application ||WB, IF, E|
|Other Accession||NP_036444, 6912472|
|Calculated MW||Predicted: 28, 33, 37 kDa |
Observed: 34, 42 kDa
|Application Notes||KIR2DS2 antibody can be used for detection of KIR2DS2 by Western blot at 1 - 2 µg/ml. For immunofluorescence start at 20 µg/mL.|
|Target/Specificity||KIR2DS2; KIR2DS2 antibody is human specific. Multiple isoforms are known to exist.|
|Reconstitution & Storage||KIR2DS2 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.|
|Precautions||KIR2DS2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor on natural killer (NK) cells for HLA-C alleles. Does not inhibit the activity of NK cells.|
|Cellular Location||Cell membrane; Single-pass type I membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells (1). The KIR proteins are classified by the number of extracellular immunoglobulin domains and by whether they have a long (L) or short (S) cytoplasmic domain (2,3). KIR proteins are thought to play an important role in regulation of the immune response (3). KIR2DS2 downregulates the cytotoxicity of NK cells upon recognition of specific class I major histocompatibility complex (MHC) molecules on target cells and is a receptor on natural killer (NK) cells for HLA-C alleles (3,4).
Colonna M and Samaridis J. Cloning of immunoglobulin-superfamily members associated with HLA-C and HLA-B recognition by human natural killer cells. Science 1995; 268:405-8.
Biassoni R, Cantoni C, Falco M, et al. The human leukocyte antigen (HLA)-C-specific "activatory" or "inhibitory" natural killer cell receptors display highly homologous extracellular domains but differ in their transmembrane and intracytoplasmic portions. J. Exp. Med. 1996; 183:645-50.
Wagtmann N, Biassoni R, Cantoni C, et al. Molecular clones of the p58 NK cell receptor reveal immunoglobulin-related molecules with diversity in both the extra- and intracellular domains. Immunity 1995; 2:439-49.
Moesta AK and Parham P. Diverse functionality among human NK cell receptors for the C1 epitope of HLA-C: KIR2DS2, KIR2DL2, and KIR2DL3. Front. Immunol. 2012; 3:336.
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