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S1PR2 Antibody

  • WB - S1PR2 Antibody ASC11940
    Western blot analysis of S1PR2 in HeLa cell lysate with S1PR2 antibody at 1 µg/ml.
  • IHC - S1PR2 Antibody ASC11940
    Immunohistochemistry of S1PR2 in mouse brain tissue with S1PR2 antibody at 10 µg/ml.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O95136
Other Accession NP_004221, 134244587
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW Predicted: 39 kDa

Observed: 50 kDa
Application Notes S1PR2 antibody can be used for detection of S1PR2 by Western blot at 1 - 2 µg/ml. Antibody can also be used for immunohistochemistry at 10 µg/ml.
Additional Information
Gene ID 9294
Target/Specificity S1PR2; S1PR2 antibody is human, mouse and rat reactive.
Reconstitution & Storage S1PR2 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.
PrecautionsS1PR2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name S1PR2
Synonyms EDG5
Function Receptor for the lysosphingolipid sphingosine 1- phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. When expressed in rat HTC4 hepatoma cells, is capable of mediating S1P-induced cell proliferation and suppression of apoptosis.
Cellular Location Cell membrane; Multi-pass membrane protein.
Research Areas
Citations (0)

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The Sphingosine 1-phosphate receptor 2 (S1PR2) protein was initially identified as G-protein coupled receptor thought to be involved in development (1) and was found to mediate sphingosine 1-phosphate (SPP)-induced cell rounding and neurite retraction (2). S1PR2 and the related protein S1PR3 (also known as EDG3) are also thought to mediate the SPP-induced cell proliferation, survival, and related signaling events (3). S1PR2 has also been found to be key regulator in acute vascular inflammation and may be a novel therapeutic target for vascular disorders (4).


MacLennan AJ, Browe CS, Gaskin AA, et al. Cloning and characterization of a putative G-protein coupled receptor potentially involved in development. Mol. Cell Neurosci. 1994; 5:201-9.
Van Brocklyn JR, Tu Z, Edsall LC, et al. Sphingosine 1-phosphate-induced cell rounding and neurite retraction are mediated by the G protein-coupled receptor H218. J. Biol. Chem. 1999; 274:4626-32.
An S, Zheng Y, and Bleu T. Sphingosine 1-phosphate-induced cell proliferation, survival, and related signaling events mediated by G protein-coupled receptors Edg3 and Edg5. J. Biol. Chem. 275:288-96.
Zhang G, Yang L, Kim GS, et al. Critical role of sphingosine-1-phosphate receptor 2 (S1PR2) in acute vascular inflammation. Blood 2013; 122:443-55.

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$ 310.00
Cat# ASC11940
(40 western blots)
Availability: 5-7days
Bulk Size
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