|Application ||WB, IHC, E|
|Other Accession||NP_060204, 8923243|
|Calculated MW||Predicted: 61 kDa; Observed: 60 kDa|
|Application Notes||PALMD antibody can be used for detection of PALMD by Western blot at 1 - 2 µg/ml. Antibody can also be used for immunohistochemistry starting at 2.5 µg/mL.|
|Target/Specificity||PALMD; PALMD antibody is human specific. At least two isoforms are known to exist.|
|Reconstitution & Storage||PALMD antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.|
|Precautions||PALMD Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Cellular Location||Cytoplasm. Cell projection, dendrite. Cell projection, dendritic spine|
|Tissue Location||Ubiquitous. Most abundant in cardiac and skeletal muscle.|
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Provided below are standard protocols that you may find useful for product applications.
Palmdelphin (PALMD) is a member of the paralemmin families that are lipid-anchored proteins having a role in the cell shape control and cell dynamics (1,2). While Paralemmin proteins typically anchor to the cytoplasm through via palmytoylation and prenylation, PALMD is found predominantly in the cytosol (3). PALMD is targeted to the nucleus to induce apoptosis in response to DNA damage (3-5). Abnormal genetic alterations in PALMD are observed in many malignant tumors (5).
Hultqvist G, Ocampo Daza D, Larhammar D, et al. Evolution of the vertebrate paralemmin gene family: ancient origin of gene duplicates suggests distinct functions. PLoS One 2012; 7:e41850.
Andreu N, Escarceller M, Feather S, et al. PALML, a novel paralemmin-related gene mapping on human chromosome 1p21. Gene 2001; 278:33-40.
Hu B, Copeland NG, Gilbert DJ, et al. The paralemmin protein family: identification of paralemmin-2, an isoform differentially spliced to AKAP2/AKAP-KL, and of palmdelphin, a more distant cytosolic relative. Biochem. Biophys. Res. Commun. 2001; 285:1369-76.
Dashzeveg N, Taira N, Lu ZG, et al. Palmdelphin, a novel target of p53 with Ser46 phosphorylation, controls cell death in response to DNA damage. Cell Death Dis. 2014; 5:e1221.
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