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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   PALMD Antibody   

PALMD Antibody

     
  • WB - PALMD Antibody ASC11943
    Western blot analysis of PALMD in human bladder tissue lysate with PALMD antibody at 1 µg/ml.
  • IHC - PALMD Antibody ASC11943
    Immunohistochemistry of PALMD in human bladder tissue with PALMD antibody at 2.5 µg/mL.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC, E
Primary Accession Q9NP74
Other Accession NP_060204, 8923243
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW Predicted: 61 kDa; Observed: 60 kDa
Application Notes PALMD antibody can be used for detection of PALMD by Western blot at 1 - 2 µg/ml. Antibody can also be used for immunohistochemistry starting at 2.5 µg/mL.
Additional Information
Gene ID 54873
Target/Specificity PALMD; PALMD antibody is human specific. At least two isoforms are known to exist.
Reconstitution & Storage PALMD antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.
PrecautionsPALMD Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PALMD
Synonyms C1orf11, PALML
Cellular Location Cytoplasm. Cell projection, dendrite. Cell projection, dendritic spine
Tissue Location Ubiquitous. Most abundant in cardiac and skeletal muscle.
Research Areas
Citations (0)

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Background

Palmdelphin (PALMD) is a member of the paralemmin families that are lipid-anchored proteins having a role in the cell shape control and cell dynamics (1,2). While Paralemmin proteins typically anchor to the cytoplasm through via palmytoylation and prenylation, PALMD is found predominantly in the cytosol (3). PALMD is targeted to the nucleus to induce apoptosis in response to DNA damage (3-5). Abnormal genetic alterations in PALMD are observed in many malignant tumors (5).

References

Hultqvist G, Ocampo Daza D, Larhammar D, et al. Evolution of the vertebrate paralemmin gene family: ancient origin of gene duplicates suggests distinct functions. PLoS One 2012; 7:e41850.
Andreu N, Escarceller M, Feather S, et al. PALML, a novel paralemmin-related gene mapping on human chromosome 1p21. Gene 2001; 278:33-40.
Hu B, Copeland NG, Gilbert DJ, et al. The paralemmin protein family: identification of paralemmin-2, an isoform differentially spliced to AKAP2/AKAP-KL, and of palmdelphin, a more distant cytosolic relative. Biochem. Biophys. Res. Commun. 2001; 285:1369-76.
Dashzeveg N, Taira N, Lu ZG, et al. Palmdelphin, a novel target of p53 with Ser46 phosphorylation, controls cell death in response to DNA damage. Cell Death Dis. 2014; 5:e1221.

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$ 320.00
Cat# ASC11943
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