|Application ||WB, IHC, E|
|Other Accession||NP_001034794, 89276766|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||Predicted: 78, 157 kDa |
Observed: 94 kDa
|Application Notes||Trophinin antibody can be used for detection of Trophinin by Western blot at 1 - 2 µg/ml. Antibody can also be used for immunohistochemistry at 10 µg/ml.|
|Target/Specificity||TRO; Trophinin antibody is human, mouse and rat reactive. Multiple isoforms of Trophinin are known to exist.|
|Reconstitution & Storage||Trophinin antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.|
|Precautions||Trophinin Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Could be involved with bystin and tastin in a cell adhesion molecule complex that mediates an initial attachment of the blastocyst to uterine epithelial cells at the time of the embryo implantation. Directly responsible for homophilic cell adhesion.|
|Tissue Location||Strong expression at implantation sites. Found in the placenta from the sixth week of pregnancy. Was localized in the cytoplasm of the syncytiotrophoblast in the chorionic villi and in endometrial decidual cells at the uteroplacental interface After week 10, the level decreased and then disappeared from placental villi. Also found in macrophages|
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Provided below are standard protocols that you may find useful for product applications.
Trophinin, also known as TRO or MAGED3, is an apical cell adhesion molecule that is implicated in the initial attachment during the process of embryo implantation and functions by mediating cell adhesion between trophoblastic and endometrial epithelial cells (1,2). Trophinin is a membrane protein expressed in chorionic villi trophoblasts and in maternal endometrial epithelial cells in an implantation-dependent manner and interacts with Bystin and Tastin, facilitating cell adhesion and embryo implantation (3,4). The induction of Trophinin expression may be a useful method for improving implantation rates and can be a potential diagnostic factor and biomarker for human cancer (4,5).
Fukuda MN, Sato T, Nakayama J, et al. Trophinin and tastin, a novel cell adhesion molecule complex with potential involvement in embryo implantation. Genes Dev. 1995; 9:1199-210.
Ma L, Yin M, Wu X, et al. Expression of trophinin and bystin identifies distinct cell types in the germinal zones of adult rat brain. Eur. J. Neurosci. 2006; 23:2265-76.
Tamura N, Sugihara K, Akama TO, et al. Trophinin-mediated cell adhesion induces apoptosis of human endometrial epithelial cells through PKC-d. Cell Cycle 2011; 10:135-43.
Chen KY, Lee YC, Lai JM, et al. Identification of trophinin as an enhancer for cell invasion and a prognostic factor for early stage lung cancer. Eur. J. Cancer. 2007; 43:782-90.
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