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LANCL2 Antibody

  • WB - LANCL2 Antibody ASC11958
    Western blot analysis of LANCL2 in human brain tissue lysate with LANCL2 antibody at 1 µg/ml.
  • IHC - LANCL2 Antibody ASC11958
    Immunohistochemistry of LANCL2 in mouse brain tissue with LANCL2 antibody at 5 µg/mL.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9NS86
Other Accession NP_061167, 8923911
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW Predicted: 50 kDa; Observed: 48 kDa
Application Notes LANCL2 antibody can be used for the detection of LANCL2 by Western blot at 1 - 2 µg/mL. Antibody can also be used for immunohistochemistry starting at 5 µg/mL.
Additional Information
Gene ID 55915
Target/Specificity LANCL2; LANCL2 antibody is human, mouse and rat reactive.
Reconstitution & Storage LANCL2 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.
PrecautionsLANCL2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms GPR69B, TASP
Function Necessary for abscisic acid (ABA) binding on the cell membrane and activation of the ABA signaling pathway in granulocytes.
Cellular Location Nucleus. Cytoplasm. Cell membrane Note=Localizes to the juxta-nuclear vesicles (PubMed:16979580) Associates with the cortical actin cytoskeleton (PubMed:16979580) Cholesterol depletion by methyl-beta-cyclodextrin causes partial dissociation from the cell membrane in vitro and an enhanced cell detachment from the matrix in vivo (PubMed:16979580). Membrane- association is important for the increased cellular sensitivity to an anticancer drug (adriamycin) (PubMed:16979580)
Tissue Location Expressed in brain and testis.
Research Areas
Citations (0)

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LANCL2 (LanC-like protein 2), also known as TASP (testis-specific adriamycin sensitivity protein) or GPR69B, is a 450 amino acid member of the LanC-like protein family (1). It is expressed highly in brain and testis and localized to the nucleus, cytoplasm and cell membrane (2,3). LANCL2 is necessary for abscisic acid (ABA) binding on the cell membrane and activation of the ABA signaling pathway in granulocytes (3,4).


Mayer H, Pongratz M, and Prohaska R. Molecular cloning, characterization, and tissue-specific expression of human LANCL2, a novel member of the LanC-like protein family. DNA Seq. 2001; 12:161-6.
Sturla L, Fresia C, Guida L, et al. Binding of abscisic acid to human LANCL2. Biochem. Biophys. Res. Commun. 2011; 415:390-5.
Landlinger C, Salzer U, and Prohaska R. Myristoylation of human LanC-like protein 2 (LANCL2) is essential for the interaction with the plasma membrane and the increase in cellular sensitivity to adriamycin. Biochim. Biophys. Acta. 2006; 1758:1759-67.
Zeng M, van der Donk WA, Chen J. Lanthionine synthetase C-like protein 2 (LanCL2) is a novel regulator of Akt. Mol. Biol. Cell 2014; 25:3954-61.

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$ 330.00
Cat# ASC11958
Availability: 5-7days
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