|Application ||WB, ICC, E|
|Other Accession||NP_055662, 188497758|
|Calculated MW||Predicted: 120 kDa |
Observed: 130 kDa
|Application Notes||UBAP2L antibody can be used for the detection of UBAP2L by Western blot at 1 - 2 µg/mL. Antibody can also be used for immunocytochemistry at 10 µg/ml.|
|Target/Specificity||UBAP2L; UBAP2L antibody is human and mouse reactive. At least four isoforms of UBAP2L are known to exist; this antibody will detect all four isoforms. This antibody is predicted to not cross-react with UBAP2.|
|Reconstitution & Storage||UBAP2L antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.|
|Precautions||UBAP2L Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays an important role in the activity of long-term repopulating hematopoietic stem cells (LT-HSCs).|
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Provided below are standard protocols that you may find useful for product applications.
The UBA domain-containing protein ubiquitin associated protein 2-like (UBAP2L), also known as NICE4, is a ubiquitously expressed 1,087 amino acid protein. UBAP2L is preferentially expressed in hematopoietic stem cell (HSC) populations and interacts with BMI1, a well-known determinant of HSC function (1). It is essential for the activity of long-term repopulating HSCs but not the BMI1-dependent repression of the Ink4a/Arf locus (1).
Bordeleau ME, Aucagne R, Chagraoui J, et al. UBAPL2L is a novel BMI1-iteracting protein essential for hematopoietic stem cell activity. Blood 2014; 124:2362-9.
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