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>   home   >   Products   >   Primary Antibodies   >   Stem Cells   >   IL-11 Antibody   

IL-11 Antibody

     
  • WB - IL-11 Antibody ASC11966
    Western blot analysis of IL-11 in Hela Cell lysate with IL-11 antibody at 1 µg/ml.
  • ICC - IL-11 Antibody ASC11966
    Immunocytochemistry of IL-11 in HeLa cells with IL-11 antibody at 10 µg/ml.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, ICC, E
Primary Accession P20809
Other Accession NP_000632, 10834994
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW Predicted: 20 kDa

Observed: 19 kDa
Application Notes IL-11 antibody can be used for the detection of IL-11 by Western blot at 1 - 2 µg/mL. Antibody can also be used for immunocytochemistry at 10 µg/ml.
Additional Information
Gene ID 3589
Target/Specificity IL-11; IL-11 antibody is human specific. At least two isoforms of IL-11 are known to exist; this antibody will only detect the longest isoform of IL-11.
Reconstitution & Storage IL-11 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.
PrecautionsIL-11 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name IL11
Function Cytokine that stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production (PubMed:2145578). Also promotes the proliferation of hepatocytes in response to liver damage. Binding to its receptor formed by IL6ST and either IL11RA1 or IL11RA2 activates a signaling cascade that promotes cell proliferation (PubMed:12919066). Signaling leads to the activation of intracellular protein kinases and the phosphorylation of STAT3.
Cellular Location Secreted
Research Areas
Citations (0)

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Background

Interleukin 11 is a pleiotropic cytokine that has multiple effects on both hematopoietic and nonhematopoietic cells. Many of the biological effects described for IL-11 overlap those for IL-6 (1). It directly stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production (2). IL-11 promotes the proliferation of hepatocytes in response to liver damage. IL-11 binds to its receptor formed by IL6ST and either IL11RA1 or IL11RA2 (3). Clinically it is used to prevent severe thrombocytopenia and the reduction of the need for platelet transfusion following myelo-suppressive chemotherapy (4).

References

Paul SR, Bennett F, Calvetti JA. Molecular cloning of a cDNA encoding interleukin-11, astromal cell-derived lymphopoietic and hematopoietic cytokine. Proc. Natl. Acad. Sci. USA 1990; 87:7512-6.
Yang YC and Yin T. Interleukin (IL)-11 mediated signal transduction. Ann. N.Y. Acad. Sci. 1995; 762:31-40.
Dimitriadis E, Robb L, Salamonsen LA. Interleukin 11 advances progesterone-induced decidualization of human endometrial stromal cells. Mol. Hum. Reprod. 2002; 8:636-43.
Andersson By U, Tani E, Andersson U. Tumor necrosis factor, interleukin 11, and leukemia inhibitory factor produced by Langerhans cells in Langerhans cell histiocytosis. J. Pediatr. Hematol. Oncol. 2004; 26:706-11.

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$ 310.00
Cat# ASC11966
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