|Application ||WB, IF, ICC, E|
|Other Accession||NP_001138666, 642597|
|Calculated MW||Predicted: 8 kDa |
Observed: 12 kDa
|Application Notes||C18orf42 antibody can be used for the detection of C18orf42 by Western blot at 1 - 2 μg/mL. Antibody can also be used for Immunocytochemistry starting at 2 μg/mL. For immunofluorescence start at 2 μg/mL.|
|Target/Specificity||C18orf42 antibody was raised against a 16 amino acid peptide from near the center of human C18orf42.|
The immunogen is located within the last 50 amino acids of C18orf42.
|Reconstitution & Storage||C18orf42 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.|
|Precautions||C18orf42 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Protein kinase A (PKA)-binding protein. Binds to type II regulatory subunits of protein kinase A (PKA) and may block the A- kinase anchoring protein (AKAP)-mediated subcellular localization of PKA (PubMed:25653177).|
|Tissue Location||Preferentially expressed in the neural tissues (PubMed:25653177).|
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Provided below are standard protocols that you may find useful for product applications.
Little is known of the function of the protein encoded by Chromosome 18 open reading frame 18 (C18orf42), but it is preferentially expressed in neuronal tissue (1). It is thought to bind to the cAMP-dependent protein kinase A (PKA) and regulation its interaction with members of the A-kinase anchoring protein (AKAP) family (1).
Fukuda M and Aizawa Y. Hypothetical gene C18orf42 encodes a novel protein kinase A-binding protein. Genes Cells 2015; 20:267-80.
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