|Application ||WB, E|
|Other Accession||NP_659443, 21450717|
|Calculated MW||Predicted: 16, 22, 23, 28 kDa |
Observed: 23 kDa
|Application Notes||SUSD3 antibody can be used for the detection of SUSD3 by Western blot at 1 - 2 µg/mL.|
|Target/Specificity||SUSD3; SUSD3 antibody is human and mouse reactive. Multiple isoforms of SUSD3 are known to exist.|
|Reconstitution & Storage||SUSD3 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.|
|Precautions||SUSD3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May play a role in breast tumorigenesis by promoting estrogen-dependent cell proliferation, cell-cell interactions and migration.|
|Cellular Location||Cell membrane; Single-pass membrane protein. Note=Prominently localized to cell-cell borders.|
|Tissue Location||Highly expressed in estrogen receptor-positive breast tumors.|
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Provided below are standard protocols that you may find useful for product applications.
Little is known of the function of the sushi domain containing 3 protein (SUSD3), but its expression has been reported in estrogen receptor-alpha (ERalpha)-positive breast tumors with decreased expression reported in aggressive malignant tumors (1,2). Recently, SUSD3 has been found to promote estrogen-dependent cell proliferation and may regulate cell-cell and cell-substrate interactions and migration in breast cancer (3). Furthermore, elevated SUSD3 mRNA levels were observed in aromatase inhibitor-responsive breast tumors, suggesting that it may also serve as a novel predictor of response to endocrine therapy and a potential therapeutic target (3).
Abba MC, Hu Y, Sun H, et al. Gene expression signature of estrogen receptor alpha status in breast cancer. BMC Genomics 2005; 6:37.
Parris TZ, Danielsson A, Nemes S, et al. Clinical implications of gene dosage and gene expression patterns in diploid breast cancer. Clin. Cancer Res. 2010; 16:3860-74.
Moy I, Todorovic V, Dubash AD, et al. Estrogen-dependent sushi domain containing 3 regulates cytoskeleton organization and migration in breast cancer cells. Oncogene 2015; 34:323-33.
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