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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   MD-2 Antibody [9F1B1]    

MD-2 Antibody [9F1B1]

  • WB - MD-2 Antibody [9F1B1]  ASC11995
    Western blot analysis of (A) 25 and (B) 125 ng of MD-2 recombinant protein with MD-2 antibody at 1 µg/mL.
  • IHC - MD-2 Antibody [9F1B1]  ASC11995
    Immunohistochemistry of MD-2 in human spleen with MD-2 antibody at 2.5 µg/mL.
  • IF - MD-2 Antibody [9F1B1]  ASC11995
    Immunofluorescence of MD2 in human spleen tissue with MD2 antibody at 20 µg/mL.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9Y6Y9
Other Accession NP_056179, 223555998
Reactivity Human, Mouse
Host Mouse
Clonality Monoclonal
Isotype IgG1
Clone Names 9F1B1
Calculated MW 18546 Da
Application Notes MD-2 antibody can be used for detection of MD-2 by Western blot at 1 µg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 µg/mL. For immunofluorescence start at 20 µg/mL.
Additional Information
Gene ID 23643
Target/Specificity LY96;
Reconstitution & Storage MD-2 monoclonal antibody can be stored at -20℃, stable for one year.
PrecautionsMD-2 Antibody [9F1B1] is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name LY96
Synonyms ESOP1, MD2
Function Cooperates with TLR4 in the innate immune response to bacterial lipopolysaccharide (LPS), and with TLR2 in the response to cell wall components from Gram-positive and Gram-negative bacteria. Enhances TLR4-dependent activation of NF-kappa-B. Cells expressing both MD2 and TLR4, but not TLR4 alone, respond to LPS.
Cellular Location Secreted, extracellular space.
Research Areas
Citations (0)

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MD-2 Monoclonal Antibody: MD-2 is a member of the Toll/interleukin-1 receptor (TIR) family, a group of proteins that include the Toll-like receptors (TLRs). TLRs are signaling molecules that recognize different pathogen-associated molecular patterns (PAMPs) and serve as an important link between the innate and adaptive immune responses. TLR4, the major signaling receptor for lipopolysaccharide (LPS), requires the binding of MD-2 to its extracellular region for maximal response to LPS. The specificity of this response is determined by the species of MD-2; e.g., human MD-2 transfected into mouse cells can cause mouse TLR4 to react to LPS analogs that are normally antagonistic to human but not mouse TLR4.


O’Neill LAJ, Fitzgerald FA, and Bowie AG. The Toll-IL-1 receptor adaptor family grows to five members. Trends in Imm. 2003; 24:286-9.
Vogel SN, Fitzgerald KA, and Fenton MJ. TLRs: differential adapter utilization by toll-like receptors mediates TLR-specific patterns of gene expression. Mol. Interv. 2003; 3:466-77.
Takeda K, Kaisho T, and Akira S. Toll-like receptors. Annu. Rev. Immunol. 2003; 21:335-76.
Janeway CA Jr and Medzhitov R. Innate immune recognition. Annu. Rev. Immunol. 2002; 20:197-216.

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$ 310.00
Cat# ASC11995
(40 western blots)
Availability: 5-7days
Bulk Size
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