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CD9 Antibody

     
  • WB - CD9 Antibody ASC12030
    Western blot analysis of CD9 in (A) human ovary, (B) human uterus, (C) human ovary tumor, and (D) human uterus tumor tissue lysate with CD9 antibody at 1 µg/ml.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession P21926
Other Accession 4502693, NP_001760, 928
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 25416 Da
Application Notes CD9 antibody can be used for Western blot at 1 - 2 µg/mL.
Additional Information
Gene ID 928
Other Names CD9 Antibody: CD9 molecule, MIC3, MRP-1, BTCC-1, DRAP-27, TSPAN29, TSPAN-29
PrecautionsCD9 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CD9
Synonyms MIC3, TSPAN29
Function Involved in platelet activation and aggregation. Regulates paranodal junction formation. Involved in cell adhesion, cell motility and tumor metastasis. Required for sperm-egg fusion.
Cellular Location Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein
Tissue Location Detected in platelets (at protein level). Expressed by a variety of hematopoietic and epithelial cells
Research Areas
Citations (0)

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Background

CD9 Antibody: CD9 is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Like other tetraspanins, CD9 is a cell surface glycoproteins play a role in many cellular processes including differentiation, adhesion, and signal transduction (1). CD9 expression plays a critical role in the suppression of cancer cell motility and metastasis. In one study, the knockdown of CD9 expression suppressed the metastatic capacity of human breast cancer cells (2), while other results have shown the opposite effect, suggesting that different proteins associated with CD9 account for its abilities to promote or suppress metastasis (3).

References

Murayama Y, Oritani K, and Tsutsui S. Novel CD9-targeted therapies in gastric cancer. World J. Gastroenterol. 2015; 21:3206-13.;Rappa G, Green TM, Karbanova J, Corbeil D, et al. Tetraspanin CD9 determines invasiveness and tumorigenicity of human breast cancer cells. Oncotarget 2015; 6:7970-91.;Zoller M. Tetraspanins: push and pull in suppressing and promoting metastasis. Nat. Rev. Cancer 2009; 9:40-55.;

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$ 330.00
Cat# ASC12030
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