|Application ||WB, E|
|Other Accession||112421127, NP_056246, 25893|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||54766 Da|
|Application Notes||TRIM58 antibody can be used for Western blot at 1 - 2 µg/mL.|
|Other Names||TRIM58 Antibody: Tripartite motif containing 58 protein, BIA2|
|Precautions||TRIM58 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||E3 ubiquitin ligase induced during late erythropoiesis. Directly binds and ubiquitinates the intermediate chain of the microtubule motor dynein (DYNC1LI1/DYNC1LI2), stimulating the degradation of the dynein holoprotein complex. May participate in the erythroblast enucleation process through regulation of nuclear polarization.|
|Tissue Location||Expressed in erythroblasts.|
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Provided below are standard protocols that you may find useful for product applications.
TRIM58 Antibody: TRIM58 is a member of the tripartite motif-containing family of proteins that frequently possess E3 ubiquitin ligase activities (1). TRIM58 is strongly expressed in erythroid lineage cells and is further upregulated during late erythroid maturation. Recent experiments suggest that TRIM58 facilitates erythroblast enucleation by ubiquitinating the intermediate chain of the microtubule motor dynein, thereby inducing proteolytic degradation (2).
Napolitano LM and Meroni G. TRIM family: Pleiotropy and diversification through homomultimer and heteromultimer formation. IUBMB Life 2012; 64:64-71.;Thom CS, Traxler EA, Khandros E, et al. Trim58 degrades dynein and regulates terminal erythropoiesis. Dev. Cell 2014; 30:688-700.;;
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