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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   TRIM58 Antibody   

TRIM58 Antibody

     
  • WB - TRIM58 Antibody ASC12033
    Western blot analysis of TRIM58 in (A) human heart tissue and (B) mouse kidney lysate with TRIM58 antibody at 1 µg/mL.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q8NG06
Other Accession 112421127, NP_056246, 25893
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 54766 Da
Application Notes TRIM58 antibody can be used for Western blot at 1 - 2 µg/mL.
Additional Information
Gene ID 25893
Other Names TRIM58 Antibody: Tripartite motif containing 58 protein, BIA2
PrecautionsTRIM58 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TRIM58
Function E3 ubiquitin ligase induced during late erythropoiesis. Directly binds and ubiquitinates the intermediate chain of the microtubule motor dynein (DYNC1LI1/DYNC1LI2), stimulating the degradation of the dynein holoprotein complex. May participate in the erythroblast enucleation process through regulation of nuclear polarization.
Tissue Location Expressed in erythroblasts.
Research Areas
Citations (0)

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Background

TRIM58 Antibody: TRIM58 is a member of the tripartite motif-containing family of proteins that frequently possess E3 ubiquitin ligase activities (1). TRIM58 is strongly expressed in erythroid lineage cells and is further upregulated during late erythroid maturation. Recent experiments suggest that TRIM58 facilitates erythroblast enucleation by ubiquitinating the intermediate chain of the microtubule motor dynein, thereby inducing proteolytic degradation (2).

References

Napolitano LM and Meroni G. TRIM family: Pleiotropy and diversification through homomultimer and heteromultimer formation. IUBMB Life 2012; 64:64-71.;Thom CS, Traxler EA, Khandros E, et al. Trim58 degrades dynein and regulates terminal erythropoiesis. Dev. Cell 2014; 30:688-700.;;

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$ 330.00
Cat# ASC12033
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