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Cav1.2 Antibody
Cav1.2 Antibody, Clone S57-46
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC, ICC/IF, IP, AM |
|---|---|
| Primary Accession | P15381 |
| Other Accession | NP_001129994.1 |
| Host | Mouse |
| Isotype | IgG1 |
| Reactivity | Human, Mouse, Rat, Hamster |
| Clonality | Monoclonal |
| Description | Mouse Anti-Rabbit Cav1.2 Monoclonal IgG1 |
| Target/Specificity | Detects ~240kDa (varies with cell background due to glycosylation). |
| Other Names | CACH3 Antibody, CACN4 Antibody, CACNA 1D Antibody, CACNL1A2 Antibody, voltage dependent L type calcium channel subunit alpha 1D Antibody, alpha-1 subunit voltage-dependent calcium channel Antibody, calcium channel voltage-dependent L type alpha 1C subunit1 Antibody, voltage-gated calcium channel alpha subunit Cav1.2 Antibody, calcium channel L type Antibody, alpha 1 polypeptide isoform 1 cardic muscle Antibody, calcium channel cardic dihydropyridine-sensitive alpha-1 subunit Antibody, voltage-gated L-type calcium channel Cav1.2 alpha 1 subunit splice variant 10 Antibody, DHPR alpha-1 subunit Antibody, Voltage-gated calcium channel subunit alpha Cav1.2 Antibody, Calcium channel L type alpha-1 polypeptide isoform 1 cardiac muscle Antibody |
| Clone Names | S57-46 |
| Immunogen | Fusion protein amino acids 1507-1733 (intracellular carboxyl terminus) of rabbit Cav1.2 |
| Purification | Protein G Purified |
| Storage | -20ºC |
| Storage Buffer | PBS pH7.4, 50% glycerol, 0.1% sodium azide |
| Shipping Temperature | Blue Ice or 4ºC |
| Certificate of Analysis | 1 µg/ml of SMC-300 was sufficient for detection of Cav1.2 in 10 µg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody. |
| Cellular Localization | Membrane | Cell Membrane |
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Provided below are standard protocols that you may find useful for product applications.
Background
Cav1.2 is a cardiac L-type calcium channel, and is important for excitation and contraction of the heart (1). It may be associated with a variant of Long QT syndrome called Timothy's syndrome (2, 3) and also with Brugada syndrome. Some references also suggest it is related to bipolar disease as well (3).
References
1. Splawski I., et al. (2004) Cell. 119 (1): 19-31.
2. Krey J.F., and Dolmetsch R. (2009) Biophysical. 96 (3): 221a-222a.
3. Crotti L., Celano G., Dagradi F. and Schwartz P.J. (2008) Orphanet J Rare Disease 3:18.
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