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KCNQ1 Antibody
KCNQ1 Antibody, Clone S37A-10
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC, ICC/IF, IP, AM |
|---|---|
| Primary Accession | P51787 |
| Other Accession | NP_000209.2 |
| Host | Mouse |
| Isotype | IgG1 |
| Reactivity | Human, Mouse, Rat, Hamster |
| Clonality | Monoclonal |
| Description | Mouse Anti-Human KCNQ1 Monoclonal IgG1 |
| Target/Specificity | Detects ~75kDa. |
| Other Names | ATFB1 Antibody, ATFB3 Antibody, FLJ26167 Antibody, IKs producing slow voltage-gated potassium channel subunit alpha Antibody, IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1 Antibody, Jervell and Lange-Nielsen syndrome 1 Antibody, JLNS1 Antibody, KCNA8 Antibody, KCNA9 Antibody, KCNQ1 Antibody, KCNQ1_HUMAN Antibody, kidney and cardiac voltage dependend K+ channel Antibody, KQT-like 1 Antibody, Kv1.9 Antibody, Kv7.1 Antibody, KVLQT1 Antibody, long (electrocardiographic) QT syndrome Antibody, Ward-Romano syndrome 1 Antibody, LQT Antibody, LQT1 Antibody, Potassium voltage-gated channel subfamily KQT member 1 Antibody, potassium voltage-gated channel KQT-like subfamily member 1 Antibody, RWS Antibody, slow delayed rectifier channel subunit Antibody, SQT2 Antibody, Voltage-gated potassium channel subunit Kv7.1 Antibody, WRS Antibody |
| Clone Names | S37A-10 |
| Immunogen | Fusion protein amino acids 2-101 of human KCNQ1 |
| Purification | Protein G Purified |
| Storage | -20ºC |
| Storage Buffer | PBS pH7.4, 50% glycerol, 0.09% sodium azide |
| Shipping Temperature | Blue Ice or 4ºC |
| Certificate of Analysis | 1 µg/ml of SMC-307 was sufficient for detection of KCNQ1 in 10 µg of COS-1 cell lysate transiently expressing KCNQ1 by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody. |
| Cellular Localization | Cell Membrane | Cytoplasmic Vesicle Membrane |
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Provided below are standard protocols that you may find useful for product applications.
Background
Kv7.1 (KvLQT1) is a potassium channel protein coded for by the gene KCNQ1. Kv7.1 is present in the cell membranes of cardiac muscle tissue and in inner ear neurons (1) among other tissues. In the cardiac cells, Kv7.1 mediates the IKs (or slow delayed rectifying K+) current that contributes to the repolarization of the cell, terminating the cardiac action potential and thereby the heart's contraction (2, 3).
References
1. Lang F., Vallon V., Knipper M., Wagenmann P. (2007) Am J Physiol. 293(4): C1187-1208.
2. Kurokawa J., et al. (2009) Channels (Austin). 3(1): 16-24.
3. Silva J., and Rudy Y. (2005) Circulation. 112(10): 1384-1391.
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