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Cav beta 1 Antibody
Cav beta 1 Antibody, Clone S7-18
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC, ICC, IP, AM |
|---|---|
| Primary Accession | P54283 |
| Other Accession | NP_059042 |
| Host | Mouse |
| Isotype | IgG1 |
| Reactivity | Human, Mouse, Rat |
| Clonality | Monoclonal |
| Description | Mouse Anti-Rat Cav beta 1 Monoclonal IgG1 |
| Target/Specificity | Detects ~80, 55kDa. No cross-reactivity against Cav Beta4. |
| Other Names | CACNB1 Antibody, CAB1 Antibody, CACNLB1 Antibody, voltage dependent L type calcium channel beta 1 subunit Antibody |
| Clone Names | S7-18 |
| Immunogen | Synthetic peptide amino acids 19-34 of rat CavB1 |
| Purification | Protein G Purified |
| Storage | -20ºC |
| Storage Buffer | PBS pH7.4, 50% glycerol, 0.09% sodium azide |
| Shipping Temperature | Blue Ice or 4ºC |
| Certificate of Analysis | 1 µg/ml of SMC-317 was sufficient for detection of Cavβ1 in 10 µg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody. |
| Cellular Localization | Cell Membrane |
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Provided below are standard protocols that you may find useful for product applications.
Background
Calcium channel, voltage-dependent, beta 1 subunit, also known as CACNB1, is a human gene. The protein encoded by this gene belongs to the calcium channel beta subunit family. It plays an important role in the calcium channel by modulating G protein inhibition, increasing peak calcium current, controlling the alpha-1 subunit membrane targeting and shifting the voltage dependence of activation and inactivation. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified (1, 2).
References
1. www.iochannels.org
2. Leyris J.P., et al. (2009) Faseb J. EPub.
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