Kv3.4 Antibody
Kv3.4 Antibody, Clone S72-16
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC, ICC/IF, IP, AM |
---|---|
Primary Accession | Q63734 |
Other Accession | NP_001116248.1 |
Host | Mouse |
Isotype | IgG1 |
Reactivity | Human, Mouse, Rat |
Clonality | Monoclonal |
Description | Mouse Anti-Rat Kv3.4 Monoclonal IgG1 |
Target/Specificity | Detects ~70kDa (100kDa in brain due to glycosylation). |
Other Names | Raw3 Antibody, Voltage-gated potassium channel subunit Kv3.4 Antibody, Potassium voltage-gated channel subfamily C member 4 Antibody |
Clone Names | S72-16 |
Immunogen | Synthetic peptide amino acids 175-192 of rat Kv3.4 |
Purification | Protein G Purified |
Storage | -20ºC |
Storage Buffer | PBS pH7.4, 50% glycerol, 0.09% sodium azide |
Shipping Temperature | Blue Ice or 4ºC |
Certificate of Analysis | 1 µg/ml of SMC-335 was sufficient for detection of Kv3.4 in 10 µg of rat brain lysate by colorimetric immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody. |
Cellular Localization | Membrane |
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Provided below are standard protocols that you may find useful for product applications.
Background
Kv3.4, a member of the Shaw subfamily, may play important roles in maintaining normal function of the corneal epithelium (1). Kv3.4 is also over-expressed in the early stages of Alzheimer’s disease, and therefore represents a novel therapeutic target for this disease (2).
References
1. Wang L., Fyffe R.E.W., and Lu L. (2004) Investigative Ophthalmology and Visual Science. 45: 1796-1803.
2. Angulo E., et al. (2004) J Neurochem. 91(3): 547-557.
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